| http://purl.uniprot.org/citations/15542592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15542592 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15542592 | http://www.w3.org/2000/01/rdf-schema#comment | "TACI is a member of the tumor necrosis factor receptor superfamily and serves as a key regulator of B cell function. TACI binds two ligands, APRIL and BAFF, with high affinity and contains two cysteine-rich domains (CRDs) in its extracellular region; in contrast, BCMA and BR3, the other known high affinity receptors for APRIL and BAFF, respectively, contain only a single or partial CRD. However, another form of TACI exists wherein the N-terminal CRD is removed by alternative splicing. We find that this shorter form is capable of ligand-induced cell signaling and that the second CRD alone (TACI_d2) contains full affinity for both ligands. Furthermore, we report the solution structure and alanine-scanning mutagenesis of TACI_d2 along with co-crystal structures of APRIL.TACI_d2 and APRIL.BCMA complexes that together reveal the mechanism by which TACI engages high affinity ligand binding through a single CRD, and we highlight sources of ligand-receptor specificity within the APRIL/BAFF system."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m411714200"xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m411714200"xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Yin J."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Yin J."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Pan B."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Pan B."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Yan M."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Yan M."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Skelton N.J."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Skelton N.J."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Wallweber H.J."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Wallweber H.J."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Hymowitz S.G."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Hymowitz S.G."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Shriver S.K."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Shriver S.K."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Starovasnik M.A."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Starovasnik M.A."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Kelley R.F."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Kelley R.F."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Patel D.R."xsd:string |
| http://purl.uniprot.org/citations/15542592 | http://purl.uniprot.org/core/author | "Patel D.R."xsd:string |