| http://purl.uniprot.org/citations/15548692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15548692 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15548692 | http://www.w3.org/2000/01/rdf-schema#comment | "The WWOX gene encodes a tumor suppressor WW domain-containing protein, Wwox. Alterations of WWOX have been demonstrated in multiple types of cancer, and introduction of Wwox into Wwox-negative tumor cells has resulted in tumor suppression and apoptosis. The Wwox protein contains two WW domains that typically bind proline-rich motifs and mediate protein-protein interactions. Recently, we have described functional cross-talk between the Wwox protein and the p53 homologue, p73. To further explore the biological function of Wwox, we investigated other interacting candidates. In this report, we demonstrate a physical and functional association between AP-2gamma transcription factor and the Wwox protein. AP-2gamma at 20q13.2 encodes a transcription factor and is frequently amplified in breast carcinoma. We show that Wwox binds to the PPPY motif of AP-2gamma via its first WW domain. Alterations of tyrosine 33 in the first WW domain of Wwox or the proline-rich motif in AP-2gamma dramatically reduce this interaction. In addition, our results demonstrate that Wwox expression triggers redistribution of nuclear AP-2gamma to the cytoplasm, hence suppressing its transactivating function. Our results suggest that Wwox tumor suppressor protein inhibits AP-2gamma oncogenic activity by sequestering it in the cytoplasm."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-04-2055"xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-04-2055"xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/author | "Croce C.M."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/author | "Croce C.M."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/author | "Weigel R.J."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/author | "Weigel R.J."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/author | "Pekarsky Y."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/author | "Pekarsky Y."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/author | "Aqeilan R.I."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/author | "Aqeilan R.I."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/author | "Herrero J.J."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/author | "Herrero J.J."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/author | "Palamarchuk A."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/author | "Palamarchuk A."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/pages | "8256-8261"xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/pages | "8256-8261"xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/title | "Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor."xsd:string |
| http://purl.uniprot.org/citations/15548692 | http://purl.uniprot.org/core/title | "Physical and functional interactions between the Wwox tumor suppressor protein and the AP-2gamma transcription factor."xsd:string |