| http://purl.uniprot.org/citations/15579309 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15579309 | http://www.w3.org/2000/01/rdf-schema#comment | "Fibroblast growth factor-23 (FGF-23), a recently identified molecule that is mutated in patients with autosomal dominant hypophosphatemic rickets (ADHR), appears to be involved in the regulation of phosphate homeostasis. Although increased levels of circulating FGF-23 were detected in patients with different phosphate-wasting disorders such as oncogenic osteomalacia (OOM) and X-linked hypophosphatemia (XLH), it is not yet clear whether FGF-23 is directly responsible for the abnormal regulation of mineral ion homeostasis and consequently bone development. To address some of these unresolved questions, we generated a mouse model, in which the entire Fgf-23 gene was replaced with the lacZ gene. Fgf-23 null (Fgf-23-/-) mice showed signs of growth retardation by day 17, developed severe hyperphosphatemia with elevated serum 1,25(OH)2D3 levels, and died by 13 weeks of age. Hyperphosphatemia in Fgf-23-/-mice was accompanied by skeletal abnormalities, as demonstrated by histological, molecular, and various other morphometric analyses. Fgf-23-/-) mice had increased total-body bone mineral content (BMC) but decreased bone mineral density (BMD) of the limbs. Overall, Fgf-23-/-mice exhibited increased mineralization, but also accumulation of unmineralized osteoid leading to marked limb deformities. Moreover, Fgf-23-/-mice showed excessive mineralization in soft tissues, including heart and kidney. To further expand our understanding regarding the role of Fgf-23 in phosphate homeostasis and skeletal mineralization, we crossed Fgf-23-/-animals with Hyp mice, the murine equivalent of XLH. Interestingly, Hyp males lacking both Fgf-23 alleles were indistinguishable from Fgf-23/-/ mice, both in terms of serum phosphate levels and skeletal changes, suggesting that Fgf-23 is upstream of the phosphate regulating gene with homologies to endopeptidases on the X chromosome (Phex) and that the increased plasma Fgf-23 levels in Hyp mice (and in XLH patients) may be at least partially responsible for the phosphate imbalance in this disorder."xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.matbio.2004.09.007"xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://purl.uniprot.org/core/author | "Taguchi T."xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://purl.uniprot.org/core/author | "Lanske B."xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://purl.uniprot.org/core/author | "Razzaque M.S."xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://purl.uniprot.org/core/author | "Juppner H."xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://purl.uniprot.org/core/author | "Hesse M."xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://purl.uniprot.org/core/author | "Yoganathan S."xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://purl.uniprot.org/core/author | "Sitara D."xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://purl.uniprot.org/core/author | "Erben R.G."xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15579309 | http://purl.uniprot.org/core/name | "Matrix Biol"xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://purl.uniprot.org/core/pages | "421-432"xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://purl.uniprot.org/core/title | "Homozygous ablation of fibroblast growth factor-23 results in hyperphosphatemia and impaired skeletogenesis, and reverses hypophosphatemia in Phex-deficient mice."xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://purl.uniprot.org/core/volume | "23"xsd:string |
| http://purl.uniprot.org/citations/15579309 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15579309 |
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