| http://purl.uniprot.org/citations/15611242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15611242 | http://www.w3.org/2000/01/rdf-schema#comment | "BCL-6 is a transcription repressor frequently deregulated in non-Hodgkin's B cell lymphomas. Its activity is also critical to germinal center development and balanced Th1/Th2 differentiation. Previous studies have suggested that NF-kappaB activity is suppressed in germinal center and lymphoma B cells that express high levels of BCL-6, and yet the reason for this is unknown. We report in this study that BCL-6 can bind to three sequence motifs in the 5' regulatory region of NF-kappaB1 in vitro and in vivo, and repress NF-kappaB1 transcription both in reporter assays and in lymphoma B cell lines. BCL-6(-/-) mice further confirm the biological relevance of BCL-6-dependent regulation of NF-kappaB1 because BCL-6 inactivation caused notable increase in p105/p50 proteins in several cell types. Among these, BCL-6(-/-) macrophage cell lines displayed a hyperproliferation phenotype that can be reversed by NF-kappaB inhibitors, e.g., N-tosyl-l-phenylalanine chloromethyl ketone and SN50, a result that is consistent with increased nuclear kappaB-binding activity of p50 homodimer and p50/p65 heterodimer. Our results demonstrate that BCL-6 can negatively regulate NF-kappaB1 expression, thereby inhibiting NF-kappaB-mediated cellular functions."xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.1.205"xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/author | "Li Z."xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/author | "Wang X."xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/author | "Yu J.J."xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/author | "Naganuma A."xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/author | "Ding B.B."xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/author | "Ye B.H."xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/author | "Stanley E.R."xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/author | "Yu R.Y."xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/author | "Dai X.M."xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/pages | "205-214"xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/title | "BCL-6 negatively regulates expression of the NF-kappaB1 p105/p50 subunit."xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15611242 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15611242 |
| http://purl.uniprot.org/citations/15611242 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15611242 |
| http://purl.uniprot.org/uniprot/P41183#attribution-A6EE13C408E56D36A7306C9ABB45B5F1 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15611242 |
| http://purl.uniprot.org/uniprot/P41183#attribution-F84C61A76FB7FFFF520A6312078097BC | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15611242 |
| http://purl.uniprot.org/uniprot/Q5ZM39#attribution-27CE3FBB94E015EC624DB3C0103F31E7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15611242 |
| http://purl.uniprot.org/uniprot/Q5RB65#attribution-27CE3FBB94E015EC624DB3C0103F31E7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15611242 |
| http://purl.uniprot.org/uniprot/#_P41183-mappedCitation-15611242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15611242 |
| http://purl.uniprot.org/uniprot/#_Q8CB25-mappedCitation-15611242 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15611242 |