| http://purl.uniprot.org/citations/15618521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15618521 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15618521 | http://www.w3.org/2000/01/rdf-schema#comment | "The ablation of the protein kinase Raf-1 renders cells hypersensitive to apoptosis despite normal regulation of extracellular signal-regulated kinases, which suggests that apoptosis protection is mediated by a distinct pathway. We used proteomic analysis of Raf-1 signaling complexes to show that Raf-1 counteracts apoptosis by suppressing the activation of mammalian sterile 20-like kinase (MST2). Raf-1 prevents dimerization and phosphorylation of the activation loop of MST2 independently of its protein kinase activity. Depletion of MST2 from Raf-1-/-mouse or human cells abrogated sensitivity to apoptosis, whereas overexpression of MST2 induced apoptosis. Conversely, depletion of Raf-1 from Raf-1+/+ mouse or human cells led to MST2 activation and apoptosis. The concomitant depletion of both Raf-1 and MST2 prevented apoptosis."xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1103233"xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.org/dc/terms/identifier | "doi:10.1126/science.1103233"xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/author | "Baccarini M."xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/author | "Baccarini M."xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/author | "Kolch W."xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/author | "Kolch W."xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/author | "O'Neill E."xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/author | "O'Neill E."xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/author | "Rushworth L."xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/author | "Rushworth L."xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/name | "Science"xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/pages | "2267-2270"xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/pages | "2267-2270"xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/title | "Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1."xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/title | "Role of the kinase MST2 in suppression of apoptosis by the proto-oncogene product Raf-1."xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/volume | "306"xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://purl.uniprot.org/core/volume | "306"xsd:string |
| http://purl.uniprot.org/citations/15618521 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15618521 |
| http://purl.uniprot.org/citations/15618521 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15618521 |