| http://purl.uniprot.org/citations/15620357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15620357 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15620357 | http://www.w3.org/2000/01/rdf-schema#comment | "The yeast MAPK pathways required for mating versus filamentous growth share multiple components yet specify distinct programs. The mating-specific MAPK, Fus3, prevents crosstalk between the two pathways by unknown mechanisms. Here we show that pheromone signaling induces Fus3-dependent degradation of Tec1, the transcription factor specific to the filamentation pathway. Degradation requires Fus3 kinase activity and a MAPK phosphorylation site in Tec1 at threonine 273. Fus3 associates with Tec1 in unstimulated cells, and active Fus3 phosphorylates Tec1 on T273 in vitro. Destruction of Tec1 requires the F box protein Dia2 (Digs-into-agar-2), and Cdc53, the Cullin of SCF (Skp1-Cdc53-F box) ubiquitin ligases. Notably, mutation of the phosphoacceptor site in Tec1, deletion of FUS3, or deletion of DIA2 results in a loss of signaling specificity such that pheromone pathway signaling erroneously activates filamentation pathway gene expression and invasive growth. Signal-induced destruction of a transcription factor for a competing pathway provides a mechanism for signaling specificity."xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.11.052"xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2004.11.052"xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/author | "Yates J.R. III"xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/author | "Cantin G.T."xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/author | "Cantin G.T."xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/author | "Madhani H.D."xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/author | "Madhani H.D."xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/author | "Bao M.Z."xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/author | "Bao M.Z."xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/author | "Schwartz M.A."xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/author | "Schwartz M.A."xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/pages | "991-1000"xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/pages | "991-1000"xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/title | "Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast."xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/title | "Pheromone-dependent destruction of the Tec1 transcription factor is required for MAP kinase signaling specificity in yeast."xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/volume | "119"xsd:string |
| http://purl.uniprot.org/citations/15620357 | http://purl.uniprot.org/core/volume | "119"xsd:string |