| http://purl.uniprot.org/citations/15629715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15629715 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15629715 | http://www.w3.org/2000/01/rdf-schema#comment | "The cellular response to DNA damage is mediated by evolutionarily conserved Ser/Thr kinases, phosphorylation of Cdc25 protein phosphatases, binding to 14-3-3 proteins, and exit from the cell cycle. To investigate DNA damage responses mediated by the p38/stress-activated protein kinase (SAPK) axis of signaling, the optimal phosphorylation motifs of mammalian p38alpha SAPK and MAPKAP kinase-2 were determined. The optimal substrate motif for MAPKAP kinase-2, but not for p38 SAPK, closely matches the 14-3-3 binding site on Cdc25B/C. We show that MAPKAP kinase-2 is directly responsible for Cdc25B/C phosphorylation and 14-3-3 binding in vitro and in response to UV-induced DNA damage within mammalian cells. Downregulation of MAPKAP kinase-2 eliminates DNA damage-induced G2/M, G1, and intra S phase checkpoints. We propose that MAPKAP kinase-2 is a new member of the DNA damage checkpoint kinase family that functions in parallel with Chk1 and Chk2 to integrate DNA damage signaling responses and cell cycle arrest in mammalian cells."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.11.021"xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2004.11.021"xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/author | "Nguyen A."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/author | "Nguyen A."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/author | "Yaffe M.B."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/author | "Yaffe M.B."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/author | "Lim D."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/author | "Lim D."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/author | "Stewart M.Q."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/author | "Stewart M.Q."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/author | "Elia A.E."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/author | "Elia A.E."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/author | "Manke I.A."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/author | "Manke I.A."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/pages | "37-48"xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/pages | "37-48"xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/title | "MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation."xsd:string |
| http://purl.uniprot.org/citations/15629715 | http://purl.uniprot.org/core/title | "MAPKAP kinase-2 is a cell cycle checkpoint kinase that regulates the G2/M transition and S phase progression in response to UV irradiation."xsd:string |