| http://purl.uniprot.org/citations/15661907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15661907 | http://www.w3.org/2000/01/rdf-schema#comment | "CD45 is dynamically repositioned within lipid rafts and the immune synapse during T cell activation, although the molecular consequences of CD45 repositioning remain unclear. In this study we examine the role of CD45 membrane compartmentalization in regulating murine T cell activation. We find that raft-localized CD45 antagonizes IL-2 production by opposing processive TCR signals, whereas raft-excluded CD45 promotes ERK-dependent polarized synaptic lipid raft clustering and IL-2 production. We propose that these dual CD45 activities ensure that only robust TCR signals proceed, whereas signals meeting threshold requirements are potentiated. Our findings highlight membrane compartmentalization as a key regulator of CD45 function and elucidate a novel signal transduction pathway by which raft-excluded CD45 positively regulates T cell activation."xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.3.1479"xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://purl.uniprot.org/core/author | "Zhang M."xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://purl.uniprot.org/core/author | "Moran M."xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://purl.uniprot.org/core/author | "Patel V.P."xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://purl.uniprot.org/core/author | "Miceli M.C."xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://purl.uniprot.org/core/author | "Round J."xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://purl.uniprot.org/core/author | "Hernandez J.D."xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://purl.uniprot.org/core/author | "Low T.A."xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://purl.uniprot.org/core/author | "Tomassian T."xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15661907 | http://purl.uniprot.org/core/name | "J Immunol"xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://purl.uniprot.org/core/pages | "1479-1490"xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://purl.uniprot.org/core/title | "CD45 signals outside of lipid rafts to promote ERK activation, synaptic raft clustering, and IL-2 production."xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://purl.uniprot.org/core/volume | "174"xsd:string |
| http://purl.uniprot.org/citations/15661907 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15661907 |
| http://purl.uniprot.org/citations/15661907 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15661907 |
| http://purl.uniprot.org/uniprot/P08575#attribution-E3DF67E0087B6433849F13C9316535B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15661907 |
| http://purl.uniprot.org/uniprot/P06800#attribution-267B789965AF43A4EB8C2417BC1D2D92 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15661907 |
| http://purl.uniprot.org/uniprot/P06800#attribution-5A13BCDBA9FACAD65E1066FDFE3D5D76 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15661907 |
| http://purl.uniprot.org/uniprot/P06800#attribution-E3DF67E0087B6433849F13C9316535B4 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15661907 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YWF2-mappedCitation-15661907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15661907 |
| http://purl.uniprot.org/uniprot/#_A0A0A6YXM4-mappedCitation-15661907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15661907 |
| http://purl.uniprot.org/uniprot/#_A1E2H6-mappedCitation-15661907 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15661907 |