| http://purl.uniprot.org/citations/15671020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15671020 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15671020 | http://www.w3.org/2000/01/rdf-schema#comment | "Cofilin, an essential regulator of actin filament dynamics, is inactivated by phosphorylation at Ser-3 and reactivated by dephosphorylation. Although cofilin undergoes dephosphorylation in response to extracellular stimuli that elevate intracellular Ca2+ concentrations, signaling mechanisms mediating Ca2+-induced cofilin dephosphorylation have remained unknown. We investigated the role of Slingshot (SSH) 1L, a member of a SSH family of protein phosphatases, in mediating Ca2+-induced cofilin dephosphorylation. The Ca2+ ionophore A23187 and Ca2+-mobilizing agonists, ATP and histamine, induced SSH1L activation and cofilin dephosphorylation in cultured cells. A23187- or histamine-induced SSH1L activation and cofilin dephosphorylation were blocked by calcineurin inhibitors or a dominant-negative form of calcineurin, indicating that calcineurin mediates Ca2+-induced SSH1L activation and cofilin dephosphorylation. Importantly, knockdown of SSH1L expression by RNA interference abolished A23187- or calcineurin-induced cofilin dephosphorylation. Furthermore, calcineurin dephosphorylated SSH1L and increased the cofilin-phosphatase activity of SSH1L in cell-free assays. Based on these findings, we suggest that Ca2+-induced cofilin dephosphorylation is mediated by calcineurin-dependent activation of SSH1L."xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m411494200"xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m411494200"xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/author | "Mizuno K."xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/author | "Mizuno K."xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/author | "Wang Y."xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/author | "Shibasaki F."xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/author | "Shibasaki F."xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/pages | "12683-12689"xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/pages | "12683-12689"xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/title | "Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin."xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/title | "Calcium signal-induced cofilin dephosphorylation is mediated by Slingshot via calcineurin."xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15671020 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15671020 |
| http://purl.uniprot.org/citations/15671020 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15671020 |
| http://purl.uniprot.org/citations/15671020 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15671020 |
| http://purl.uniprot.org/citations/15671020 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15671020 |