| http://purl.uniprot.org/citations/15674244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15674244 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15674244 | http://www.w3.org/2000/01/rdf-schema#comment | "A small number of mammalian retinal ganglion cells act as photoreceptors for regulating certain non-image forming photoresponses. These intrinsically photosensitive retinal ganglion cells express the putative photopigment melanopsin. Ablation of the melanopsin gene renders these cells insensitive to light; however, the precise role of melanopsin in supporting cellular photosensitivity is unconfirmed. Here we show that heterologous expression of human melanopsin in a mouse paraneuronal cell line (Neuro-2a) is sufficient to render these cells photoreceptive. Under such conditions, melanopsin acts as a sensory photopigment, coupled to a native ion channel via a G-protein signalling cascade, to drive physiological light detection. The melanopsin photoresponse relies on the presence of cis-isoforms of retinaldehyde and is selectively sensitive to short-wavelength light. We also present evidence to show that melanopsin functions as a bistable pigment in this system, having an intrinsic photoisomerase regeneration function that is chromatically shifted to longer wavelengths."xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature03344"xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.org/dc/terms/identifier | "doi:10.1038/nature03344"xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/author | "Bellingham J."xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/author | "Bellingham J."xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/author | "Hankins M.W."xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/author | "Hankins M.W."xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/author | "Tarttelin E.E."xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/author | "Tarttelin E.E."xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/author | "Lucas R.J."xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/author | "Lucas R.J."xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/author | "Melyan Z."xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/author | "Melyan Z."xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/pages | "741-745"xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/pages | "741-745"xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/title | "Addition of human melanopsin renders mammalian cells photoresponsive."xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/title | "Addition of human melanopsin renders mammalian cells photoresponsive."xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/volume | "433"xsd:string |
| http://purl.uniprot.org/citations/15674244 | http://purl.uniprot.org/core/volume | "433"xsd:string |