| http://purl.uniprot.org/citations/1569568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1569568 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1569568 | http://www.w3.org/2000/01/rdf-schema#comment | "The crystal structure of recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) has been determined at 2.8 A resolution using multiple isomorphous replacement techniques. There are two molecules in the crystallographic asymmetric unit, which are related by an approximate non-crystallographic 2-fold axis. The overall structure is highly compact and globular with a predominantly hydrophobic core. The main structural feature of rhGM-CSF is a four alpha-helix bundle, which represents approximately 42% of the structure. The helices are arranged in a left-handed antiparallel bundle with two overhand connections. Within the connections is a two-stranded antiparallel beta-sheet. The tertiary structure of rhGM-CSF has a topology similar to that of porcine growth factor and interferon-beta. Most of the proposed critical regions for receptor binding are located on a continuous surface at one end of the molecule that includes the C terminus."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.org/dc/terms/identifier | "doi:10.1016/0022-2836(92)90470-5"xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.org/dc/terms/identifier | "doi:10.1016/0022-2836(92)90470-5"xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/author | "Ealick S.E."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/author | "Ealick S.E."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/author | "Cook W.J."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/author | "Cook W.J."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/author | "Bugg C.E."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/author | "Bugg C.E."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/author | "Walter M.R."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/author | "Walter M.R."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/author | "Trotta P.P."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/author | "Trotta P.P."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/author | "Nagabhushan T.L."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/author | "Nagabhushan T.L."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/pages | "1075-1085"xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/pages | "1075-1085"xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/title | "Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor."xsd:string |
| http://purl.uniprot.org/citations/1569568 | http://purl.uniprot.org/core/title | "Three-dimensional structure of recombinant human granulocyte-macrophage colony-stimulating factor."xsd:string |