| http://purl.uniprot.org/citations/15696168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15696168 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15696168 | http://www.w3.org/2000/01/rdf-schema#comment | "Naive T cell activation requires signaling by the T cell receptor and by nonclonotypic cell surface receptors. The most important costimulatory protein is the monovalent homodimer CD28, which interacts with CD80 and CD86 expressed on antigen-presenting cells. Here we present the crystal structure of a soluble form of CD28 in complex with the Fab fragment of a mitogenic antibody. Structural comparisons redefine the evolutionary relationships of CD28-related proteins, antigen receptors and adhesion molecules and account for the distinct ligand-binding and stoichiometric properties of CD28 and the related, inhibitory homodimer CTLA-4. Cryo-electron microscopy-based comparisons of complexes of CD28 with mitogenic and nonmitogenic antibodies place new constraints on models of antibody-induced receptor triggering. This work completes the initial structural characterization of the CD28-CTLA-4-CD80-CD86 signaling system."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1170"xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1170"xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Stuart D.I."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Stuart D.I."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Yu C."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Yu C."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Hanke T."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Hanke T."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Gilbert R.J."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Gilbert R.J."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Davis S.J."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Davis S.J."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Esnouf R.M."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Esnouf R.M."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Walse B."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Walse B."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Evans E.J."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Evans E.J."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Fennelly J.A."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Fennelly J.A."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Hunig T."xsd:string |
| http://purl.uniprot.org/citations/15696168 | http://purl.uniprot.org/core/author | "Hunig T."xsd:string |