| http://purl.uniprot.org/citations/15725944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15725944 | http://www.w3.org/2000/01/rdf-schema#comment | "Recent studies have indicated that caveolae are enriched in a variety of signaling molecules, some of which are associated with cardiomyocyte hypertrophy. Caveolin-3, a major constituent of cardiac caveolae, has been suggested to interact with several signaling molecules. We investigated the morphologic changes of caveolae and caveolin-3 expression in hypertrophied cardiomyocytes induced by an alpha1-adrenergic agonist. Cultured rat neonatal cardiomyocytes were used for the experiments. Phenylephrine induced cellular hypertrophy associated with an increase of the number of caveolae and an up-regulation of caveolin-3. Although PMA increased the number of caveolae and the caveolin-3 expression, the extent of these up-regulations was less than that by phenylephrine. Moreover, ionomycin increased the number of caveolae and up-regulated caveolin-3 as much as phenylephrine. Phenylephrine-induced up-regulations of caveolae and caveolin-3 expression were inhibited by BAPTA, suggesting that the intracellular Ca2+ is involved in those regulations. Inhibitors of calcineurin and Ca2+calmodulin-dependent kinase II attenuated the phenylephrine-induced up-regulation of caveolin-3. In pressure-overloaded rat hearts, caveolin-3 protein levels were increased compared with sham-operated rats. In conclusion, the number of caveolae and the expression of caveolin-3 were up-regulated in rat hypertrophied cardiomyocytes, possibly via the alterations of intracellular Ca2+ and protein kinase C."xsd:string |
| http://purl.uniprot.org/citations/15725944 | http://purl.org/dc/terms/identifier | "doi:10.1097/01.fjc.0000152029.53997.57"xsd:string |
| http://purl.uniprot.org/citations/15725944 | http://purl.uniprot.org/core/author | "Kikuchi T."xsd:string |
| http://purl.uniprot.org/citations/15725944 | http://purl.uniprot.org/core/author | "Oka N."xsd:string |
| http://purl.uniprot.org/citations/15725944 | http://purl.uniprot.org/core/author | "Imaizumi T."xsd:string |
| http://purl.uniprot.org/citations/15725944 | http://purl.uniprot.org/core/author | "Miyazaki H."xsd:string |
| http://purl.uniprot.org/citations/15725944 | http://purl.uniprot.org/core/author | "Koga A."xsd:string |
| http://purl.uniprot.org/citations/15725944 | http://purl.uniprot.org/core/author | "Ohmura H."xsd:string |
| http://purl.uniprot.org/citations/15725944 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15725944 | http://purl.uniprot.org/core/name | "J Cardiovasc Pharmacol"xsd:string |
| http://purl.uniprot.org/citations/15725944 | http://purl.uniprot.org/core/pages | "204-210"xsd:string |
| http://purl.uniprot.org/citations/15725944 | http://purl.uniprot.org/core/title | "Behavior of caveolae and caveolin-3 during the development of myocyte hypertrophy."xsd:string |
| http://purl.uniprot.org/citations/15725944 | http://purl.uniprot.org/core/volume | "45"xsd:string |
| http://purl.uniprot.org/citations/15725944 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15725944 |
| http://purl.uniprot.org/citations/15725944 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15725944 |
| http://purl.uniprot.org/uniprot/P51638#attribution-08C9996C915EF1F813460F9F625103E9 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15725944 |
| http://purl.uniprot.org/uniprot/#_P51638-mappedCitation-15725944 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15725944 |
| http://purl.uniprot.org/uniprot/P51638 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/15725944 |