| http://purl.uniprot.org/citations/15728360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15728360 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15728360 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the platelet-derived growth factor (PDGF) ligand family are known to play important roles in wound healing and fibrotic disease. We show that both transient and stable expression of PDGF-C results in the development of liver fibrosis consisting of the deposition of collagen in a pericellular and perivenular pattern that resembles human alcoholic and nonalcoholic fatty liver disease. Fibrosis in PDGF-C transgenic mice, as demonstrated by staining and hydroxyproline content, is preceded by activation and proliferation of hepatic stellate cells, as shown by collagen, alpha-smooth muscle actin and glial fibrillary acidic protein staining and between 8 and 12 months of age is followed by the development of liver adenomas and hepatocellular carcinomas. The hepatic expression of a number of known profibrotic genes, including type beta1 TGF, PDGF receptors alpha and beta, and tissue inhibitors of matrix metalloproteinases-1 and -2, increased by 4 weeks of age. Increased PDGF receptor alpha and beta protein levels were associated with activation of extracellular regulated kinase-1 and -2 and protein kinase B. At 9 months of age, PDGF-C transgenic mice had enlarged livers associated with increased fibrosis, steatosis, cell dysplasia, and hepatocellular carcinomas. These studies indicate that hepatic expression of PDGF-C induces a number of profibrotic pathways, suggesting that this growth factor may act as an initiator of fibrosis. Moreover, PDGF-C transgenic mice represent a unique model for the study of hepatic fibrosis progressing to tumorigenesis."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0409722102"xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0409722102"xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Fausto N."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Fausto N."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Campbell J.S."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Campbell J.S."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Haugen H.S."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Haugen H.S."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Hughes S.D."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Hughes S.D."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Bauer R.L."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Bauer R.L."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Gilbertson D.G."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Gilbertson D.G."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Haran A.C."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Haran A.C."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Holdren M.S."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Holdren M.S."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Odell M.M."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Odell M.M."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Palmer T.E."xsd:string |
| http://purl.uniprot.org/citations/15728360 | http://purl.uniprot.org/core/author | "Palmer T.E."xsd:string |