| http://purl.uniprot.org/citations/15767565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15767565 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15767565 | http://www.w3.org/2000/01/rdf-schema#comment | "DAF-16/forkhead transcription factor, the downstream target of the insulin-like signaling in Caenorhabditis elegans, is indispensable for both lifespan regulation and stress resistance. Here, we demonstrate that c-Jun N-terminal kinase (JNK) is a positive regulator of DAF-16 in both processes. Our genetic analysis suggests that the JNK pathway acts in parallel with the insulin-like signaling pathway to regulate lifespan and both pathways converge onto DAF-16. We also show that JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus. Our findings define an interaction between two well conserved proteins, JNK-1 and DAF-16, and provide a mechanism by which JNK regulates longevity and stress resistance."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0500749102"xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0500749102"xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/author | "Jiang F."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/author | "Jiang F."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/author | "Mukhopadhyay A."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/author | "Mukhopadhyay A."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/author | "Tissenbaum H.A."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/author | "Tissenbaum H.A."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/author | "Davis R.J."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/author | "Davis R.J."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/author | "Oh S.W."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/author | "Oh S.W."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/author | "Svrzikapa N."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/author | "Svrzikapa N."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/pages | "4494-4499"xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/pages | "4494-4499"xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/title | "JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16."xsd:string |
| http://purl.uniprot.org/citations/15767565 | http://purl.uniprot.org/core/title | "JNK regulates lifespan in Caenorhabditis elegans by modulating nuclear translocation of forkhead transcription factor/DAF-16."xsd:string |