| http://purl.uniprot.org/citations/1577270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1577270 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1577270 | http://www.w3.org/2000/01/rdf-schema#comment | "The NF-kappa B transcription factor complex is comprised of two subunits, p50 and p65, that share significant homology to the rel oncogene. We have isolated a cDNA encoding a novel 66-kD rel-related protein, designated I-Rel. Unlike other rel-related proteins, I-Rel does not interact with DNA. I-Rel forms heterodimers with p50, however, and greatly attenuates its DNA-binding activity--an effect probably resulting from the presence of a domain inhibitory to DNA binding present within the 121 amino-terminal residues of I-Rel. In contrast, I-Rel does not associate with p65. Transfection experiments demonstrate that I-Rel suppresses NF-kappa B-induced transcription, probably through its association with p50. Expression of I-Rel mRNA is induced by mitogenic stimulation and accumulates after the appearance of p50 transcripts. Our findings suggest that p50 and I-Rel are components of a feedback pathway where expression of I-Rel may modulate indirectly the expression of genes responsive to the NF-kappa B transcription factor complex."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.6.5.745"xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.org/dc/terms/identifier | "doi:10.1101/gad.6.5.745"xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/author | "Chen C.H."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/author | "Maher M."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/author | "Maher M."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/author | "Rosen C.A."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/author | "Rosen C.A."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/author | "Klement J.F."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/author | "Klement J.F."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/author | "Coleman T.A."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/author | "Coleman T.A."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/author | "Ruben S.M."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/author | "Ruben S.M."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/name | "Genes Dev."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/pages | "745-760"xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/pages | "745-760"xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/title | "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity."xsd:string |
| http://purl.uniprot.org/citations/1577270 | http://purl.uniprot.org/core/title | "I-Rel: a novel rel-related protein that inhibits NF-kappa B transcriptional activity."xsd:string |