| http://purl.uniprot.org/citations/15790681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15790681 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15790681 | http://www.w3.org/2000/01/rdf-schema#comment | "Scurfy mice, which are deficient in a functional Foxp3, exhibit a severe lymphoproliferative disorder and display generalized over-production of cytokines. Here, we show that, among the Foxp transcriptional factor family, which includes Foxp1, Foxp2, and Foxp3, only Foxp3 has the ability to inhibit IL-2, IL-4, and IFN-gamma production by primary T helper cells. We found that Foxp3 physically associates with the Rel family transcription factors, nuclear factor of activated T cells (NFAT) and NF-kappaB, and blocks their ability to induce the endogenous expression of their target genes, including key cytokine genes. More importantly, T cells derived from scurfy mice have a dramatic increase in nuclear factor of activated T cells (NFAT) and NF-kappa B transcriptional activity compared with the T cells derived from WT mice. Furthermore, complementation of Foxp3 in scurfy-derived T cells lowers the NFAT and NF-kappa B transcriptional activity to the physiological level. Finally, we show that myelin proteolipid protein-specific autoreactive T cells transduced with Foxp3 cannot mediate experimental autoimmune encephalomyelitis, providing further support that Foxp3 suppresses the effector function of autoreactive T cells. Foxp3 has already been associated with the generation of CD4(+)CD25+ regulatory T cells; our data additionally demonstrate that Foxp3 suppresses the effector functions of T helper cells by directly inhibiting the activity of two key transcription factors, NFAT and NF-kappa B, which are essential for cytokine gene expression and T cell functions."xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0501675102"xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0501675102"xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/author | "Bettelli E."xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/author | "Bettelli E."xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/author | "Dastrange M."xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/author | "Dastrange M."xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/author | "Oukka M."xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/author | "Oukka M."xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/name | "Proc. Natl. Acad. Sci. U.S.A."xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/pages | "5138-5143"xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/pages | "5138-5143"xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/title | "Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells."xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/title | "Foxp3 interacts with nuclear factor of activated T cells and NF-kappa B to repress cytokine gene expression and effector functions of T helper cells."xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/15790681 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15790681 |
| http://purl.uniprot.org/citations/15790681 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15790681 |
| http://purl.uniprot.org/citations/15790681 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15790681 |
| http://purl.uniprot.org/citations/15790681 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15790681 |