| http://purl.uniprot.org/citations/1579166 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1579166 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1579166 | http://www.w3.org/2000/01/rdf-schema#comment | "The protein Lck (p56lck) has a relative molecular mass of 56,000 and belongs to the Src family of tyrosine kinases. It is expressed exclusively in lymphoid cells, predominantly in thymocytes and peripheral T cells. Lck associates specifically with the cytoplasmic domains of both CD4 and CD8 T-cell surface glycoproteins and interacts with the beta-chain of the interleukin-2 receptor, which implicates Lck activity in signal transduction during thymocyte ontogeny and activation of mature T cells. Here we generate an lck null mutation by homologous recombination in embryonic stem cells to evaluate the role of p56lck in T-cell development and activation. Lck-deficient mice show a pronounced thymic atrophy, with a dramatic reduction in the double-positive (CD4+CD8+) thymocyte population. Mature, single-positive thymocytes are not detectable in these mice and there are only very few peripheral T cells. These results illustrate the crucial role of this T-cell-specific tyrosine kinase in the thymocyte development."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.org/dc/terms/identifier | "doi:10.1038/357161a0"xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.org/dc/terms/identifier | "doi:10.1038/357161a0"xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Siderovski D.P."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Siderovski D.P."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Wakeham A."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Wakeham A."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Molina T.J."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Molina T.J."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Veillette A."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Veillette A."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Narendran A."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Narendran A."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Paige C.J."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Paige C.J."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "van Ewijk W."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "van Ewijk W."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Kishihara K."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Kishihara K."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Hartmann K.U."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Hartmann K.U."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Timms E."xsd:string |
| http://purl.uniprot.org/citations/1579166 | http://purl.uniprot.org/core/author | "Timms E."xsd:string |