| http://purl.uniprot.org/citations/15806148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15806148 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15806148 | http://www.w3.org/2000/01/rdf-schema#comment | "Members of the LAP protein family, LET-413 in Caenorhabditis elegans, Scribble in Drosophila melanogaster, and Erbin, Lano, Densin-180 and hScrib in mammals, have conserved structural features. LET-413 and Scribble are junctional proteins involved in establishing and maintaining epithelial cell polarity. scribble also behaves as a neoplastic tumor suppressor gene. We show here that, in epithelial cells, hScrib is recruited at cell-cell junctions in an E-cadherin-dependent manner as shown by calcium switch assays in MDCK cells, re-expression of E-cadherin in MDA-231 cells treated by 5-Aza-2'-deoxycytidine (5Aza), and siRNA experiments. hScrib is restricted at the basolateral membrane of epithelial cells by its LRR domain, and is enriched in Triton X-100-insoluble fractions. In breast cancers, most lobular tumors did not express hScrib and E-cadherin while ductal tumors had a less frequent downregulation of hScrib. Our data provide additional insights on the modalities of recruitment of hScrib at the cell-cell junctions, and establish a potential link between the E-cadherin and hScrib tumor suppressors."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1208632"xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1208632"xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Borg J.-P."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Borg J.-P."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Audebert S."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Audebert S."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Navarro C."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Navarro C."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Marchetto S."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Marchetto S."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Nola S."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Nola S."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Santoni M.-J."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Santoni M.-J."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Birnbaum D."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Birnbaum D."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Ginestier C."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Ginestier C."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Isnardon D."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Isnardon D."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Jacquemier J."xsd:string |
| http://purl.uniprot.org/citations/15806148 | http://purl.uniprot.org/core/author | "Jacquemier J."xsd:string |