| http://purl.uniprot.org/citations/15824120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15824120 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15824120 | http://www.w3.org/2000/01/rdf-schema#comment | "SUMO (small ubiquitin-like modifier) is a member of the ubiquitin family of proteins. SUMO targets include proteins involved in numerous roles including nuclear transport and transcriptional regulation. The previous finding that mutant ataxin-1[82Q] disrupted promyelocytic leukemia (PML) oncogenic domains prompted us to determine whether ataxin-1 disrupts another component of PML oncogenic domains, Sp100 (100-kDa Speckled protein). Similar to the PML protein, mutant ataxin-1[82Q] redistributed Sp100 to mutant ataxin-1[82Q] nuclear inclusions. Based on the ability of PML and Sp100 to be covalently modified by SUMO, we investigated the ability of ataxin-1 to be SUMOylated. SUMO-1 was found to covalently modify the polyglutamine repeat protein ataxin-1. There was a decrease in ataxin-1 SUMOylation in the presence of the expanded polyglutamine tract, ataxin-1[82Q]. The phospho-mutant, ataxin-1[82Q]-S776A, restored SUMO levels to those of wild-type ataxin-1[30Q]. SUMOylation of ataxin-1 was dependent on a functional nuclear localization signal. Ataxin-1 SUMOylation was mapped to at least five lysine residues. Lys(16), Lys(194) preceding the polyglutamine tract, Lys(610)/Lys(697) in the C-terminal ataxin high mobility group domain, and Lys(746) all contribute to ataxin-1 SUMOylation."xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m501677200"xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m501677200"xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/author | "Orr H.T."xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/author | "Orr H.T."xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/author | "Zoghbi H.Y."xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/author | "Zoghbi H.Y."xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/author | "Riley B.E."xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/author | "Riley B.E."xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/pages | "21942-21948"xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/pages | "21942-21948"xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/title | "SUMOylation of the polyglutamine repeat protein, ataxin-1, is dependent on a functional nuclear localization signal."xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/title | "SUMOylation of the polyglutamine repeat protein, ataxin-1, is dependent on a functional nuclear localization signal."xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://purl.uniprot.org/core/volume | "280"xsd:string |
| http://purl.uniprot.org/citations/15824120 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15824120 |
| http://purl.uniprot.org/citations/15824120 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15824120 |
| http://purl.uniprot.org/citations/15824120 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15824120 |
| http://purl.uniprot.org/citations/15824120 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15824120 |