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http://purl.uniprot.org/citations/15860628http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15860628http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15860628http://www.w3.org/2000/01/rdf-schema#comment"The clock proteins PERIOD1 (PER1) and PERIOD2 (PER2) play essential roles in a negative transcriptional feedback loop that generates circadian rhythms in mammalian cells. We identified two PER1-associated factors, NONO and WDR5, that modulate PER activity. The reduction of NONO expression by RNA interference (RNAi) attenuated circadian rhythms in mammalian cells, and fruit flies carrying a hypomorphic allele were nearly arrhythmic. WDR5, a subunit of histone methyltransferase complexes, augmented PER-mediated transcriptional repression, and its reduction by RNAi diminished circadian histone methylations at the promoter of a clock gene."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.org/dc/terms/identifier"doi:10.1126/science.1107373"xsd:string
http://purl.uniprot.org/citations/15860628http://purl.org/dc/terms/identifier"doi:10.1126/science.1107373"xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Vilbois F."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Vilbois F."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Rosbash M."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Rosbash M."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Schibler U."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Schibler U."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Fleury-Olela F."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Fleury-Olela F."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Brown S.A."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Brown S.A."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Kadener S."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Kadener S."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Ripperger J."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/author"Ripperger J."xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/name"Science"xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/pages"693-696"xsd:string
http://purl.uniprot.org/citations/15860628http://purl.uniprot.org/core/pages"693-696"xsd:string