| http://purl.uniprot.org/citations/15882625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15882625 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15882625 | http://www.w3.org/2000/01/rdf-schema#comment | "Different classes of endosomes exhibit a characteristic intracellular steady-state distribution governed by interactions with the cytoskeleton. We found a kinesin-3, KIF16B, that transports early endosomes to the plus end of microtubules in a process regulated by the small GTPase Rab5 and its effector, the phosphatidylinositol-3-OH kinase hVPS34. In vivo, KIF16B overexpression relocated early endosomes to the cell periphery and inhibited transport to the degradative pathway. Conversely, expression of dominant-negative mutants or ablation of KIF16B by RNAi caused the clustering of early endosomes to the perinuclear region, delayed receptor recycling to the plasma membrane, and accelerated degradation. These results suggest that KIF16B, by regulating the plus end motility of early endosomes, modulates the intracellular localization of early endosomes and the balance between receptor recycling and degradation. We propose that this mechanism could have important implications for signaling."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.02.017"xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.02.017"xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Habermann B."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Habermann B."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Cabezas A."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Cabezas A."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Stenmark H."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Stenmark H."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Zerial M."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Zerial M."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Severin F."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Severin F."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Gillooly D."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Gillooly D."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Hoepfner S."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Hoepfner S."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Runge A."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/author | "Runge A."xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/name | "Cell"xsd:string |
| http://purl.uniprot.org/citations/15882625 | http://purl.uniprot.org/core/name | "Cell"xsd:string |