| http://purl.uniprot.org/citations/15895093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15895093 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15895093 | http://www.w3.org/2000/01/rdf-schema#comment | "Lens epithelium-derived growth factor (LEDGF)/p75 is the dominant binding partner of HIV-1 integrase (IN) in human cells. We have determined the NMR structure of the integrase-binding domain (IBD) in LEDGF and identified amino acid residues essential for the interaction. The IBD is a compact right-handed bundle composed of five alpha-helices. Based on folding topology, the IBD is structurally related to a diverse family of alpha-helical proteins that includes eukaryotic translation initiation factor eIF4G and karyopherin-beta. LEDGF residues essential for the interaction with IN were localized to interhelical loop regions of the bundle structure. Interaction-defective IN mutants were previously shown to cripple replication although they retained catalytic function. The initial structure determination of a host cell factor that tightly binds to a retroviral enzyme lays the groundwork for understanding enzyme-host interactions important for viral replication."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb937"xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.org/dc/terms/identifier | "doi:10.1038/nsmb937"xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/author | "Rahman S."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/author | "Rahman S."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/author | "Wagner G."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/author | "Wagner G."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/author | "Engelman A."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/author | "Engelman A."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/author | "Cherepanov P."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/author | "Cherepanov P."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/author | "Sun Z.-Y."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/author | "Sun Z.-Y."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/author | "Maertens G."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/author | "Maertens G."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/name | "Nat. Struct. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/pages | "526-532"xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/pages | "526-532"xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/title | "Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75."xsd:string |
| http://purl.uniprot.org/citations/15895093 | http://purl.uniprot.org/core/title | "Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75."xsd:string |