| http://purl.uniprot.org/citations/15895326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15895326 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15895326 | http://www.w3.org/2000/01/rdf-schema#comment | "Using a large sample of cases and controls from a single center, we show that a T-->C substitution in exon 9 (Y402H) of the complement factor H gene is strongly associated with susceptibility to age-related macular degeneration, the most common cause of blindness in the elderly. Frequency of the C allele was 0.61 in cases, versus 0.34 in age-matched controls (P<1x10(-24)). Genotype frequencies also differ markedly between cases and controls (chi2=112.68 [2 degrees of freedom]; P<1x10(-24)). A multiplicative model fits the data well, and we estimate the population frequency of the high-risk C allele to be 0.39 (95% confidence interval 0.36-0.42) and the genotype relative risk to be 2.44 (95% confidence interval 2.08-2.83) for TC heterozygotes and 5.93 (95% confidence interval 4.33-8.02) for CC homozygotes."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.org/dc/terms/identifier | "doi:10.1086/431426"xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.org/dc/terms/identifier | "doi:10.1086/431426"xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Li M."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Shah S."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Shah S."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Abecasis G.R."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Abecasis G.R."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Branham K.E.H."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Branham K.E.H."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Hoh J."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Hoh J."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Ott J."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Ott J."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Swaroop A."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Swaroop A."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Zareparsi S."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Zareparsi S."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Klein R.J."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/author | "Klein R.J."xsd:string |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15895326 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |