| http://purl.uniprot.org/citations/15911346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15911346 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15911346 | http://www.w3.org/2000/01/rdf-schema#comment | "The mechanisms implicated in the aggregation of ubiquitinated proteins detected in neurodegenerative disorders remain elusive. We report that prostaglandin J2 (PGJ2), an endogenous product of inflammation, up-regulates sequestosome 1/p62 in a time- and dose-dependent manner in human neuroblastoma SK-N-SH cells. We previously demonstrated that prostaglandins of the J2 series inhibit ubiquitin hydrolases, such as UCH-L1. Herein, we show that sequestosome 1/p62 is co-localized with ubiquitinated proteins and the ubiquitin hydrolase UCH-L1 in cytoplasmic aggregates induced by PGJ2. Preventing sequestosome 1/p62 up-regulation by RNA interference abolishes the aggregation but not the accumulation of ubiquitinated proteins or PGJ2 cytotoxicity. Sequestosome 1/p62 is known to bind poly-ubiquitinated proteins through its ubiquitin-associated domain. Our data support the notion that sequestosome 1/p62 up-regulation under stress conditions contributes to the "sequestration" of poly-ubiquitinated proteins into aggregates. However, the overwhelming accumulation of ubiquitinated proteins, rather than their aggregation, is likely to be an important contributor to PGJ2 cytotoxicity."xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2005.02.011"xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.mcn.2005.02.011"xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/author | "Wang Z."xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/author | "Figueiredo-Pereira M.E."xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/author | "Figueiredo-Pereira M.E."xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/name | "Mol. Cell. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/name | "Mol. Cell. Neurosci."xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/pages | "222-231"xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/pages | "222-231"xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/title | "Inhibition of sequestosome 1/p62 up-regulation prevents aggregation of ubiquitinated proteins induced by prostaglandin J2 without reducing its neurotoxicity."xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/title | "Inhibition of sequestosome 1/p62 up-regulation prevents aggregation of ubiquitinated proteins induced by prostaglandin J2 without reducing its neurotoxicity."xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://purl.uniprot.org/core/volume | "29"xsd:string |
| http://purl.uniprot.org/citations/15911346 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15911346 |
| http://purl.uniprot.org/citations/15911346 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15911346 |
| http://purl.uniprot.org/citations/15911346 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15911346 |
| http://purl.uniprot.org/citations/15911346 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15911346 |
| http://purl.uniprot.org/uniprot/Q13501 | http://purl.uniprot.org/core/citation | http://purl.uniprot.org/citations/15911346 |
| http://purl.uniprot.org/uniprot/Q13501#attribution-B12863FF7C3485E9FE7C7AE564332C67 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15911346 |