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http://purl.uniprot.org/citations/15916812http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15916812http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15916812http://www.w3.org/2000/01/rdf-schema#comment"Under physiological conditions normally characterised by low tissue infiltration of eosinophils, a conspicuous number of these cells are attracted into the human and ruminant ovary. Eosinophils suddenly increase in the thecal layer of the preovulatory follicle and corpus luteum at very early development. Currently, we only have a limited understanding of the mechanism for the recruitment of the ovarian eosinophils. Eotaxin (CCL11) may be one of the chemoattractants involved in stimulating eosinophils to migrate selectively into ovary. As a prerequisite for the analysis of eotaxin expression in the bovine ovary, we determined the complete bovine eotaxin mRNA sequence since it was not available from databases. The bovine eotaxin is the first member of the monocyte chemoattractant protein (MCP)/eotaxin subfamily with two mRNA isoforms varying in length in the untranslated 3'-untranslated region. The unusual amino-acid sequence of bovine eotaxin contains structural features that are so far known to be characteristic for MCP, but not eotaxin. In our microchemotaxis assays, recombinant bovine eotaxin showed a functional pattern orthologous to known eotaxins. Thus, the chimeric structure of bovine eotaxin did not affect the favoured chemotactic activity on eosinophils. Semiquantitative RT-PCR was used to investigate the expression of eotaxin in different regions of the bovine ovary. We only detected faint eotaxin mRNA signals that did not indicate physiological significance even in stimulated granulosa cell cultures, follicle-derived macrophages or fibroblasts. Taken together, bovine eotaxin attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary. Its unusual chimeric structure confirms the unity of the MCP/eotaxin subfamily of CC chemokines and distinguishes it from other CC chemokine subfamilies."xsd:string
http://purl.uniprot.org/citations/15916812http://purl.org/dc/terms/identifier"doi:10.1016/j.vetimm.2005.03.013"xsd:string
http://purl.uniprot.org/citations/15916812http://purl.org/dc/terms/identifier"doi:10.1016/j.vetimm.2005.03.013"xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/author"Aust G."xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/author"Aust G."xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/author"Vogel B."xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/author"Vogel B."xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/author"Klinder A."xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/author"Klinder A."xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/author"Sittig D."xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/author"Sittig D."xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/name"Vet. Immunol. Immunopathol."xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/name"Vet. Immunol. Immunopathol."xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/pages"67-77"xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/pages"67-77"xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/title"Bovine eotaxin (CCL11) -- an unusual member of the eotaxin group -- attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary."xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/title"Bovine eotaxin (CCL11) -- an unusual member of the eotaxin group -- attracts eosinophils in vitro but is not responsible for eosinophilia in the ovary."xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/volume"107"xsd:string
http://purl.uniprot.org/citations/15916812http://purl.uniprot.org/core/volume"107"xsd:string
http://purl.uniprot.org/citations/15916812http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15916812
http://purl.uniprot.org/citations/15916812http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/15916812
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