| http://purl.uniprot.org/citations/15920476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15920476 | http://www.w3.org/2000/01/rdf-schema#comment | "SNARE proteins (soluble NSF-attachment protein receptors) are thought to be central components of the exocytotic mechanism in neurosecretory cells, but their precise function remained unclear. Here, we show that each of the vesicle-associated SNARE proteins (v-SNARE) of a chromaffin granule, synaptobrevin II or cellubrevin, is sufficient to support Ca(2+)-dependent exocytosis and to establish a pool of primed, readily releasable vesicles. In the absence of both proteins, secretion is abolished, without affecting biogenesis or docking of granules indicating that v-SNAREs are absolutely required for granule exocytosis. We find that synaptobrevin II and cellubrevin differentially control the pool of readily releasable vesicles and show that the v-SNARE's amino terminus regulates the vesicle's primed state. We demonstrate that dynamics of fusion pore dilation are regulated by v-SNAREs, indicating their action throughout exocytosis from priming to fusion of vesicles."xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600696"xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/author | "Zhao Y."xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/author | "Rettig J."xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/author | "Takamori S."xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/author | "Bruns D."xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/author | "Matti U."xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/author | "Borisovska M."xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/author | "Glyvuk N."xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/author | "Sudhof T."xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/author | "Tsytsyura Y."xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/name | "EMBO J"xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/pages | "2114-2126"xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/title | "v-SNAREs control exocytosis of vesicles from priming to fusion."xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://purl.uniprot.org/core/volume | "24"xsd:string |
| http://purl.uniprot.org/citations/15920476 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/15920476 |
| http://purl.uniprot.org/citations/15920476 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/15920476 |
| http://purl.uniprot.org/uniprot/P63044#attribution-31C0604AD79A2E2BA10B5F870E450B8B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15920476 |
| http://purl.uniprot.org/uniprot/P63024#attribution-31C0604AD79A2E2BA10B5F870E450B8B | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/15920476 |
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| http://purl.uniprot.org/uniprot/#_A0A0N4SUV3-mappedCitation-15920476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15920476 |
| http://purl.uniprot.org/uniprot/#_P63011-mappedCitation-15920476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15920476 |
| http://purl.uniprot.org/uniprot/#_P63024-mappedCitation-15920476 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/15920476 |