| http://purl.uniprot.org/citations/1593633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1593633 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1593633 | http://www.w3.org/2000/01/rdf-schema#comment | "The X-ray crystal structures of three forms of the enzyme aspartate aminotransferase (EC 2.6.1.1) from chicken heart mitochondria have been refined by least-squares methods: holoenzyme with the co-factor pyridoxal-5'-phosphate bound at pH 7.5 (1.9 A resolution), holoenzyme with pyridoxal-5'-phosphate bound at pH 5.1 (2.3 A resolution) and holoenzyme with the co-factor pyridoxamine-5'-phosphate bound at pH 7.5 (2.2 A resolution). The crystallographic agreement factors [formula: see text] for the structures are 0.166, 0.130 and 0.131, respectively, for all data in the resolution range from 10.0 A to the limit of diffraction for each structure. The secondary, super-secondary and domain structures of the pyridoxal-phosphate holoenzyme at pH 7.5 are described in detail. The surface area of the interface between the monomer subunits of this dimeric alpha 2 protein is unusually large, indicating a very stable dimer. This is consistent with biochemical data. Both subunit and domain interfaces are relatively smooth compared with other proteins. The interactions of the protein with its co-factor are described and compared among the three structures. Observed changes in co-factor conformation may be related to spectral changes and the energetics of the catalytic reaction. Small but significant adjustments of the protein to changes in co-factor conformation are seen. These adjustments may be accommodated by small rigid-body shifts of secondary structural elements, and by packing defects in the protein core."xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.org/dc/terms/identifier | "doi:10.1016/0022-2836(92)90935-d"xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.org/dc/terms/identifier | "doi:10.1016/0022-2836(92)90935-d"xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/author | "Jansonius J.N."xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/author | "Jansonius J.N."xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/author | "McPhalen C.A."xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/author | "McPhalen C.A."xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/author | "Vincent M.G."xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/author | "Vincent M.G."xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/name | "J. Mol. Biol."xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/pages | "495-517"xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/pages | "495-517"xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/title | "X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase."xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/title | "X-ray structure refinement and comparison of three forms of mitochondrial aspartate aminotransferase."xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/volume | "225"xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://purl.uniprot.org/core/volume | "225"xsd:string |
| http://purl.uniprot.org/citations/1593633 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1593633 |
| http://purl.uniprot.org/citations/1593633 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1593633 |
| http://purl.uniprot.org/citations/1593633 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1593633 |
| http://purl.uniprot.org/citations/1593633 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1593633 |