| http://purl.uniprot.org/citations/15944249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15944249 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15944249 | http://www.w3.org/2000/01/rdf-schema#comment | "High mobility group box 1 (HMGB1) is an abundant and conserved nuclear protein that is released by necrotic cells and acts in the extracellular environment as a primary proinflammatory signal. In this study we show that human dendritic cells, which are specialized in Ag presentation to T cells, actively release their own HMGB1 into the extracellular milieu upon activation. This secreted HMGB1 is necessary for the up-regulation of CD80, CD83, and CD86 surface markers of human dendritic cells and for IL-12 production. The HMGB1 secreted by dendritic cells is also required for the clonal expansion, survival, and functional polarization of naive T cells. Using neutralizing Abs and receptor for advanced glycation end product-deficient (RAGE(-/-)) cells, we demonstrate that RAGE is required for the effect of HMGB1 on dendritic cells. HMGB1/RAGE interaction results in downstream activation of MAPKs and NF-kappaB. The use of an ancient signal of necrosis, HMGB1, by dendritic cells to sustain their own maturation and for activation of T lymphocytes represents a profitable evolutionary mechanism."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.12.7506"xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.org/dc/terms/identifier | "doi:10.4049/jimmunol.174.12.7506"xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Herrmann M."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Herrmann M."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Arnold B."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Arnold B."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Bianchi M.E."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Bianchi M.E."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Voll R.E."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Voll R.E."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Nawroth P.P."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Nawroth P.P."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Baruah P."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Baruah P."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Dumitriu I.E."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Dumitriu I.E."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Manfredi A.A."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Manfredi A.A."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Rovere-Querini P."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Rovere-Querini P."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Valentinis B."xsd:string |
| http://purl.uniprot.org/citations/15944249 | http://purl.uniprot.org/core/author | "Valentinis B."xsd:string |