DESCRIBE <http://purl.uniprot.org/citations/15955981>

Subject	Predicate	Object
http://purl.uniprot.org/citations/15955981	http://www.w3.org/1999/02/22-rdf-syntax-ns#type	http://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/15955981	http://www.w3.org/2000/01/rdf-schema#comment	" Background The ocular fetal vasculature normally regresses by apoptosis but for unknown reasons fails to regress in the human disease persistent fetal vasculature. Objective To investigate whether proapoptotic Bcl-2 members, Bax and Bak, are involved in fetal vasculature regression. Methods Adult eyes from mice deficient in Bax and/or Bak were examined grossly and histologically for persistence of fetal vasculature. Vessels were identified by the presence of lumens and erythrocytes and by Factor VIII labeling. Eyes from postnatal day 7 mice were processed for terminal deoxynucleotidyl transferase-mediated deoxyuridine triphosphate nick-end labeling (TUNEL) analysis to determine if deficiency of Bax and Bak results in defective developmental apoptosis. Results Only bax(-/-)bak(-/-) eyes retained fetal vasculature into adulthood. This vasculature consisted of a hyaloid artery emerging from the optic nerve head and intravitreal and perilental vessels but not a pupillary membrane. At postnatal day 7, wild-type but not bax(-/-)bak(-/-) eyes had TUNEL-positive cells in the fetal vasculature. Conclusions These data demonstrate that Bax and Bak serve overlapping functions in fetal vasculature regression, emphasizing the importance of apoptosis in developmental remodeling. Clinical Relevance Disruption of Bax and Bak results in persistent fetal vasculature in knockout mice, providing a model of the human disease persistent fetal vasculature to investigate its etiology and potential therapies."xsd:string
http://purl.uniprot.org/citations/15955981	http://purl.org/dc/terms/identifier	"doi:10.1001/archopht.123.6.797"xsd:string
http://purl.uniprot.org/citations/15955981	http://purl.uniprot.org/core/author	"Hahn P."xsd:string
http://purl.uniprot.org/citations/15955981	http://purl.uniprot.org/core/author	"Lindsten T."xsd:string
http://purl.uniprot.org/citations/15955981	http://purl.uniprot.org/core/author	"Thompson C.B."xsd:string
http://purl.uniprot.org/citations/15955981	http://purl.uniprot.org/core/author	"Bennett J."xsd:string
http://purl.uniprot.org/citations/15955981	http://purl.uniprot.org/core/author	"Dunaief J.L."xsd:string
http://purl.uniprot.org/citations/15955981	http://purl.uniprot.org/core/author	"Tolentino M."xsd:string
http://purl.uniprot.org/citations/15955981	http://purl.uniprot.org/core/date	"2005"xsd:gYear
http://purl.uniprot.org/citations/15955981	http://purl.uniprot.org/core/name	"Arch Ophthalmol"xsd:string
http://purl.uniprot.org/citations/15955981	http://purl.uniprot.org/core/pages	"797-802"xsd:string
http://purl.uniprot.org/citations/15955981	http://purl.uniprot.org/core/title	"Persistent fetal ocular vasculature in mice deficient in bax and bak."xsd:string
http://purl.uniprot.org/citations/15955981	http://purl.uniprot.org/core/volume	"123"xsd:string
http://purl.uniprot.org/citations/15955981	http://www.w3.org/2004/02/skos/core#exactMatch	http://purl.uniprot.org/pubmed/15955981
http://purl.uniprot.org/citations/15955981	http://xmlns.com/foaf/0.1/primaryTopicOf	https://pubmed.ncbi.nlm.nih.gov/15955981
http://purl.uniprot.org/uniprot/O08734#attribution-A6DE3B086F8440552959EF4A73ABA1A1	http://purl.uniprot.org/core/source	http://purl.uniprot.org/citations/15955981
http://purl.uniprot.org/uniprot/Q07813#attribution-A6DE3B086F8440552959EF4A73ABA1A1	http://purl.uniprot.org/core/source	http://purl.uniprot.org/citations/15955981
http://purl.uniprot.org/uniprot/#_A0A165ELP6-mappedCitation-15955981	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15955981
http://purl.uniprot.org/uniprot/#_Q07813-mappedCitation-15955981	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15955981
http://purl.uniprot.org/uniprot/#_A0A1B0GT35-mappedCitation-15955981	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15955981
http://purl.uniprot.org/uniprot/#_A0A1B0GT81-mappedCitation-15955981	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15955981
http://purl.uniprot.org/uniprot/#_A0A1B0GTA4-mappedCitation-15955981	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15955981
http://purl.uniprot.org/uniprot/#_F7CUQ1-mappedCitation-15955981	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15955981
http://purl.uniprot.org/uniprot/#_A0A1B0GS13-mappedCitation-15955981	http://www.w3.org/1999/02/22-rdf-syntax-ns#object	http://purl.uniprot.org/citations/15955981