| http://purl.uniprot.org/citations/15960975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15960975 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15960975 | http://www.w3.org/2000/01/rdf-schema#comment | "A stable complex containing MLL1 and MOF has been immunoaffinity purified from a human cell line that stably expresses an epitope-tagged WDR5 subunit. Stable interactions between MLL1 and MOF were confirmed by reciprocal immunoprecipitation, cosedimentation, and cotransfection analyses, and interaction sites were mapped to MLL1 C-terminal and MOF zinc finger domains. The purified complex has a robust MLL1-mediated histone methyltransferase activity that can effect mono-, di-, and trimethylation of H3 K4 and a MOF-mediated histone acetyltransferase activity that is specific for H4 K16. Importantly, both activities are required for optimal transcription activation on a chromatin template in vitro and on an endogenous MLL1 target gene, Hox a9, in vivo. These results indicate an activator-based mechanism for joint MLL1 and MOF recruitment and targeted methylation and acetylation and provide a molecular explanation for the closely correlated distribution of H3 K4 methylation and H4 K16 acetylation on active genes."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.04.031"xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.cell.2005.04.031"xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Dou Y."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Dou Y."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Chait B.T."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Chait B.T."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Tackett A.J."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Tackett A.J."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Allis C.D."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Allis C.D."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Roeder R.G."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Roeder R.G."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Smith E.R."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Smith E.R."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Hess J.L."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Hess J.L."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Fukuda A."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Fukuda A."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Milne T.A."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Milne T.A."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Wysocka J."xsd:string |
| http://purl.uniprot.org/citations/15960975 | http://purl.uniprot.org/core/author | "Wysocka J."xsd:string |