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| http://purl.uniprot.org/citations/15964792 | http://www.w3.org/2000/01/rdf-schema#comment | "The transcriptional activator NF-Y is a heterotrimeric complex composed of NF-YA, NF-YB, and NF-YC, which specifically binds the CCAAT consensus present in about 30% of eukaryotic promoters. All three subunits contain evolutionarily conserved core regions, which comprise a histone fold motif (HFM) in the case of NF-YB and NF-YC. Our results of in vitro binding studies and nuclear import assays reveal two different transport mechanisms for NF-Y subunits. While NF-YA is imported by an importin beta-mediated pathway, the NF-YB/NF-YC heterodimer is translocated into the nucleus in an importin 13-dependent manner. We define a nonclassical nuclear localization signal (ncNLS) in NF-YA, and mutational analysis indicates that positively charged amino acid residues in the ncNLS are required for nuclear targeting of NF-YA. Importin beta binding is restricted to the monomeric, uncomplexed NF-YA subunit. In contrast, the nuclear import of NF-YB and NF-YC requires dimer formation. Only the NF-YB/NF-YC dimer, but not the monomeric components, are recognized by importin 13 and are imported into the nucleus. Importin 13 competes with NF-YA for binding to the NF-YB/NF-YC dimer. Our data suggest that a distinct binding platform derived from the HFM of both subunits, NF-YB/NF-YC, mediates those interactions."xsd:string |
| http://purl.uniprot.org/citations/15964792 | http://purl.org/dc/terms/identifier | "doi:10.1128/mcb.25.13.5339-5354.2005"xsd:string |
| http://purl.uniprot.org/citations/15964792 | http://purl.uniprot.org/core/author | "Albig W."xsd:string |
| http://purl.uniprot.org/citations/15964792 | http://purl.uniprot.org/core/author | "Doenecke D."xsd:string |
| http://purl.uniprot.org/citations/15964792 | http://purl.uniprot.org/core/author | "Baake M."xsd:string |
| http://purl.uniprot.org/citations/15964792 | http://purl.uniprot.org/core/author | "Kahle J."xsd:string |
| http://purl.uniprot.org/citations/15964792 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/15964792 | http://purl.uniprot.org/core/name | "Mol Cell Biol"xsd:string |
| http://purl.uniprot.org/citations/15964792 | http://purl.uniprot.org/core/pages | "5339-5354"xsd:string |
| http://purl.uniprot.org/citations/15964792 | http://purl.uniprot.org/core/title | "Subunits of the heterotrimeric transcription factor NF-Y are imported into the nucleus by distinct pathways involving importin beta and importin 13."xsd:string |
| http://purl.uniprot.org/citations/15964792 | http://purl.uniprot.org/core/volume | "25"xsd:string |
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