| http://purl.uniprot.org/citations/15995708 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15995708 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/15995708 | http://www.w3.org/2000/01/rdf-schema#comment | "Ligation of the chemokine receptor CCR2 on monocytes and macrophages with its ligand CCL2 results in activation of the cascade consisting of phosphatidylinositol-3-OH kinase (PI(3)K), the small G protein Rac and lamellipodium protrusion. We show here that a unique clathrin heavy-chain repeat homology protein, FROUNT, directly bound activated CCR2 and formed clusters at the cell front during chemotaxis. Overexpression of FROUNT amplified the chemokine-elicited PI(3)K-Rac-lamellipodium protrusion cascade and subsequent chemotaxis. Blocking FROUNT function by using a truncated mutant or antisense strategy substantially diminished signaling via CCR2. In a mouse peritonitis model, suppression of endogenous FROUNT markedly prevented macrophage infiltration. Thus, FROUNT links activated CCR2 to the PI(3)K-Rac-lamellipodium protrusion cascade and could be a therapeutic target in chronic inflammatory immune diseases associated with macrophage infiltration."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1222"xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1222"xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Motomura K."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Motomura K."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Terashima Y."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Terashima Y."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Haga T."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Haga T."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Matsushima K."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Matsushima K."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Hamada T."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Hamada T."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Kanegasaki S."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Kanegasaki S."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Suwa M."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Suwa M."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Murai M."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Murai M."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Enomoto M."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Enomoto M."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Ezaki T."xsd:string |
| http://purl.uniprot.org/citations/15995708 | http://purl.uniprot.org/core/author | "Ezaki T."xsd:string |