| http://purl.uniprot.org/citations/16025118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16025118 | http://www.w3.org/2000/01/rdf-schema#comment | "Loss of the adenomatous polyposis coli (APC) protein is a common initiating event in colon cancer. Here we show that thymocyte-specific loss of APC deregulated beta-catenin signaling and suppressed Notch-dependent transcription. These events promoted the proliferation of cells of the double-negative 3 and 4 stages and reduced rearrangements between the variable, diversity and joining regions of the gene encoding T cell receptor (TCR) beta, encouraging developmental progression of aberrant thymocytes lacking pre-TCR and alphabeta TCR. Simultaneously, the loss of APC prolonged the mitotic metaphase-to-anaphase checkpoint and impaired chromosome segregation, blocking development beyond the double-negative 4 stage. The result was extensive thymic atrophy and increased frequencies of thymocytes with chromosomal abnormalities. Thus, loss of APC in immature thymocytes has consequences distinct from those of deregulation of beta-catenin signaling and is essential for T cell differentiation."xsd:string |
| http://purl.uniprot.org/citations/16025118 | http://purl.org/dc/terms/identifier | "doi:10.1038/ni1228"xsd:string |
| http://purl.uniprot.org/citations/16025118 | http://purl.uniprot.org/core/author | "Guo Z."xsd:string |
| http://purl.uniprot.org/citations/16025118 | http://purl.uniprot.org/core/author | "Chang R."xsd:string |
| http://purl.uniprot.org/citations/16025118 | http://purl.uniprot.org/core/author | "Gounari F."xsd:string |
| http://purl.uniprot.org/citations/16025118 | http://purl.uniprot.org/core/author | "Dose M."xsd:string |
| http://purl.uniprot.org/citations/16025118 | http://purl.uniprot.org/core/author | "Cowan J."xsd:string |
| http://purl.uniprot.org/citations/16025118 | http://purl.uniprot.org/core/author | "Khazaie K."xsd:string |
| http://purl.uniprot.org/citations/16025118 | http://purl.uniprot.org/core/author | "Gounaris E."xsd:string |
| http://purl.uniprot.org/citations/16025118 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16025118 | http://purl.uniprot.org/core/name | "Nat Immunol"xsd:string |
| http://purl.uniprot.org/citations/16025118 | http://purl.uniprot.org/core/pages | "800-809"xsd:string |
| http://purl.uniprot.org/citations/16025118 | http://purl.uniprot.org/core/title | "Loss of adenomatous polyposis coli gene function disrupts thymic development."xsd:string |
| http://purl.uniprot.org/citations/16025118 | http://purl.uniprot.org/core/volume | "6"xsd:string |
| http://purl.uniprot.org/citations/16025118 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16025118 |
| http://purl.uniprot.org/citations/16025118 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16025118 |
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| http://purl.uniprot.org/uniprot/Q02248#attribution-768D2689186FA366AA5B1A97A96794C5 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16025118 |
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| http://purl.uniprot.org/uniprot/#_D3Z5Q1-mappedCitation-16025118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16025118 |
| http://purl.uniprot.org/uniprot/#_E9Q6A9-mappedCitation-16025118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16025118 |
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| http://purl.uniprot.org/uniprot/#_E9QLQ9-mappedCitation-16025118 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16025118 |