| http://purl.uniprot.org/citations/16061658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16061658 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16061658 | http://www.w3.org/2000/01/rdf-schema#comment | "The WW domain-containing oxidoreductase, WWOX, is a tumor suppressor that is deleted or altered in several cancer types. We recently showed that WWOX interacts with p73 and AP-2gamma and suppresses their transcriptional activity. Yes-associated protein (YAP), also containing WW domains, was shown to associate with p73 and enhance its transcriptional activity. In addition, YAP interacts with ErbB-4 receptor tyrosine kinase and acts as transcriptional coactivator of the COOH-terminal fragment (CTF) of ErbB-4. Stimulation of ErbB-4-expressing cells with 12-O-tetradecanoylphorbol-13-acetate (TPA) results in the proteolytic cleavage of its cytoplasmic domain and translocation of this domain to the nucleus. Here we report that WWOX physically associates with the full-length ErbB-4 via its first WW domain. Coexpression of WWOX and ErbB-4 in HeLa cells followed by treatment with TPA results in the retention of ErbB-4 in the cytoplasm. Moreover, in MCF-7 breast carcinoma cells, expressing high levels of endogenous WWOX, endogenous ErbB-4 is also retained in the cytoplasm. In addition, our results show that interaction of WWOX and ErbB-4 suppresses transcriptional coactivation of CTF by YAP in a dose-dependent manner. A mutant form of WWOX lacking interaction with ErbB-4 has no effect on this coactivation of ErbB-4. Furthermore, WWOX is able to inhibit coactivation of p73 by YAP. In summary, our data indicate that WWOX antagonizes the function of YAP by competing for interaction with ErbB-4 and other targets and thus affect its transcriptional activity."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-05-1150"xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.org/dc/terms/identifier | "doi:10.1158/0008-5472.can-05-1150"xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Sudol M."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Sudol M."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Croce C.M."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Croce C.M."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Pekarsky Y."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Pekarsky Y."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Aqeilan R.I."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Aqeilan R.I."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Palamarchuk A."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Palamarchuk A."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Trapasso F."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Trapasso F."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Donati V."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Donati V."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Kaou M."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/author | "Kaou M."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |
| http://purl.uniprot.org/citations/16061658 | http://purl.uniprot.org/core/name | "Cancer Res."xsd:string |