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Aim

To investigate the role of CXCL16 in the pathogenesis of immunological liver injury and to explore the possible mechanism of T lymphocyte infiltration regulated by CXCL16.

Methods

Immunological liver injury in murine model was induced by Bacille Calmette-Guerin and lipopolysaccharide. Expression pattern and distribution of CXCL16 were examined by real-time quantitative RT-PCR and immunohistochemical analysis. Anti-CXCL16 antibody was administrated in vivo to investigate its effect on T-cell recruitment and acute hepatic necrosis. The survival of murine model was also evaluated.

Results

The murine immunological liver injury model was successfully established. CXCL16 expression increased and predominantly distributed in periportal areas and vascular endothelia in injured liver tissues. Administration of anti-CXCL16 Ab protected the mice from death and acute liver damage. Approximately 70% of the mice survived for 72 h in the anti-CXCL16 Ab treatment group, whereas 80% died within 72 h in control Ab group. The number of liver-infiltrating T lymphocytes was significantly reduced from 1.01 x 10(7) to 3.52 x 10(6)/liver, compared with control Ab treatment.

Conclusion

CXCL16 is involved in immunological liver injury by regulating T lymphocyte infiltration in liver tissue."xsd:string
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http://purl.uniprot.org/citations/16124049http://purl.uniprot.org/core/author"Cheng J."xsd:string
http://purl.uniprot.org/citations/16124049http://purl.uniprot.org/core/author"Chu Y.W."xsd:string
http://purl.uniprot.org/citations/16124049http://purl.uniprot.org/core/author"Xu H.B."xsd:string
http://purl.uniprot.org/citations/16124049http://purl.uniprot.org/core/author"Gong Y.P."xsd:string
http://purl.uniprot.org/citations/16124049http://purl.uniprot.org/core/author"Xiong S.D."xsd:string
http://purl.uniprot.org/citations/16124049http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16124049http://purl.uniprot.org/core/name"World J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/16124049http://purl.uniprot.org/core/pages"4979-4985"xsd:string
http://purl.uniprot.org/citations/16124049http://purl.uniprot.org/core/title"CXCL16 participates in pathogenesis of immunological liver injury by regulating T lymphocyte infiltration in liver tissue."xsd:string
http://purl.uniprot.org/citations/16124049http://purl.uniprot.org/core/volume"11"xsd:string
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