| http://purl.uniprot.org/citations/16127164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16127164 | http://www.w3.org/2000/01/rdf-schema#comment | "De-regulations in insulin and insulin-like growth factor (IGF) pathways may contribute to hepatocellular carcinoma. Although intracellular insulin receptor substrate-2 (IRS-2) is the main effector of insulin signaling in the liver, its role in hepatocarcinogenesis is unknown. Here, we show that IRS-2 was overexpressed in two murine models of hepatocarcinogenesis: administration of diethylnitrosamine and hepatic overexpression of SV40 large T antigen. In both models, IRS-2 overexpression was detected in preneoplastic lesions and at higher levels in tumoral nodules. IRS-2 overexpression associated with IGF-2 and IRS-1 overexpression and with GSK-3beta inhibition. Increased expression of IRS-2 was also detected in human hepatocellular carcinoma specimens and hepatoma cell lines. In murine and human hepatoma cells, IRS-2 protein induction associated with increased IRS-2 mRNA levels. The functionality of IRS-2 was demonstrated in Hep 3 B cells, in which IRS-2 tyrosine phosphorylation and its association with phosphatidylinositol-3 kinase were induced by IGF-2. Moreover, down-regulation of IRS-2 expression increased apoptosis in these cells. In conclusion, we demonstrate that IRS-2 is overexpressed in human and murine hepatocellular carcinoma. The emergence of IRS-2 overexpression at preneoplastic stages during experimental hepatocarcinogenesis and its protective effect against apoptosis suggest that IRS-2 contributes to liver tumor progression."xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://purl.org/dc/terms/identifier | "doi:10.1016/s0002-9440(10)62058-5"xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://purl.uniprot.org/core/author | "Lacombe M.L."xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://purl.uniprot.org/core/author | "Wendum D."xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://purl.uniprot.org/core/author | "Lecluse Y."xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://purl.uniprot.org/core/author | "Rey C."xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://purl.uniprot.org/core/author | "Desbois-Mouthon C."xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://purl.uniprot.org/core/author | "Housset C."xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://purl.uniprot.org/core/author | "Boissan M."xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://purl.uniprot.org/core/author | "Beurel E."xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16127164 | http://purl.uniprot.org/core/name | "Am J Pathol"xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://purl.uniprot.org/core/pages | "869-877"xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://purl.uniprot.org/core/title | "Overexpression of insulin receptor substrate-2 in human and murine hepatocellular carcinoma."xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://purl.uniprot.org/core/volume | "167"xsd:string |
| http://purl.uniprot.org/citations/16127164 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16127164 |
| http://purl.uniprot.org/citations/16127164 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16127164 |
| http://purl.uniprot.org/uniprot/#_L8ECA6-mappedCitation-16127164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16127164 |
| http://purl.uniprot.org/uniprot/#_O88970-mappedCitation-16127164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16127164 |
| http://purl.uniprot.org/uniprot/#_P81122-mappedCitation-16127164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16127164 |
| http://purl.uniprot.org/uniprot/#_Q3U2I0-mappedCitation-16127164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16127164 |
| http://purl.uniprot.org/uniprot/#_Q9UP29-mappedCitation-16127164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16127164 |
| http://purl.uniprot.org/uniprot/#_Q8TF73-mappedCitation-16127164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16127164 |
| http://purl.uniprot.org/uniprot/#_Q96RG4-mappedCitation-16127164 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16127164 |