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http://purl.uniprot.org/citations/16127745http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16127745http://www.w3.org/2000/01/rdf-schema#comment"

Aim

The genes were divided into seven categories according to biological function; apoptosis-related, immune response-related, signal transduction-related, cell cycle-related, cell growth-related, stress response-related and transcription-related genes.

Methods

We compared the gene expression profiles of SNU-C4 cells between amygdalin-treated (5 mg/mL, 24 h) and non-treated groups using cDNA microarray analysis. We selected genes downregulated in cDNA microarray and investigated mRNA levels of the genes by RT-PCR.

Results

Microarray showed that amygdalin downregulated especially genes belonging to cell cycle category: exonuclease 1 (EXO1), ATP-binding cassette, sub-family F, member 2 (ABCF2), MRE11 meiotic recombination 11 homolog A (MRE11A), topoisomerase (DNA) I (TOP1), and FK506 binding protein 12-rapamycin-associated protein 1 (FRAP1). RT-PCR analysis revealed that mRNA levels of these genes were also decreased by amygdalin treatment in SNU-C4 human colon cancer cells.

Conclusion

These results suggest that amygdalin have an anticancer effect via downregulation of cell cycle-related genes in SNU-C4 human colon cancer cells, and might be used for therapeutic anticancer drug."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.org/dc/terms/identifier"doi:10.3748/wjg.v11.i33.5156"xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/author"Lee J.H."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/author"Yoon S.H."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/author"Jung K.H."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/author"Jeong J.S."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/author"Hong S.P."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/author"Chung J.H."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/author"Park H.J."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/author"Joo W.S."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/author"Han L.S."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/author"Yim S.V."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/author"Uhm Y.K."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/author"Zheng L.T."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/name"World J Gastroenterol"xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/pages"5156-5161"xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/title"Amygdalin inhibits genes related to cell cycle in SNU-C4 human colon cancer cells."xsd:string
http://purl.uniprot.org/citations/16127745http://purl.uniprot.org/core/volume"11"xsd:string
http://purl.uniprot.org/citations/16127745http://www.w3.org/2004/02/skos/core#exactMatchhttp://purl.uniprot.org/pubmed/16127745
http://purl.uniprot.org/citations/16127745http://xmlns.com/foaf/0.1/primaryTopicOfhttps://pubmed.ncbi.nlm.nih.gov/16127745
http://purl.uniprot.org/uniprot/P11387#attribution-819F14A6D56EEF6288D86CB9A9D85A51http://purl.uniprot.org/core/sourcehttp://purl.uniprot.org/citations/16127745