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http://purl.uniprot.org/citations/16153896http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16153896http://www.w3.org/1999/02/22-rdf-syntax-ns#typehttp://purl.uniprot.org/core/Journal_Citation
http://purl.uniprot.org/citations/16153896http://www.w3.org/2000/01/rdf-schema#comment"We showed in this study that cells deficient of the BRCA1-associated BACH1 helicase, also known as BRIP1, failed to elicit homologous recombination (HR) after DNA double-stranded breaks (DSBs). BACH1-deficient cells were also sensitive to mitomycin C (MMC) and underwent MMC-induced chromosome instability. Moreover, we identified a homozygous nonsense mutation in BACH1 in a FA-J patient-derived cell line and could not detect BACH1 protein in this cell line. Expression of wild-type BACH1 in this cell line reduced the accumulation of cells at G2/M phases following exposure to DNA crosslinkers, a characteristic of Fanconi anemia (FA) cells. These results support the conclusion that BACH1 is FANCJ."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.org/dc/terms/identifier"doi:10.1016/j.ccr.2005.08.004"xsd:string
http://purl.uniprot.org/citations/16153896http://purl.org/dc/terms/identifier"doi:10.1016/j.ccr.2005.08.004"xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Jin Z."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Jin Z."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Peng M."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Peng M."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Zhang J."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Zhang F."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Zhang F."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Powell S."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Powell S."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Andreassen P.R."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Andreassen P.R."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Cantor S.B."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Cantor S.B."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Litman R."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/author"Litman R."xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/date"2005"xsd:gYear
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/name"Cancer Cell"xsd:string
http://purl.uniprot.org/citations/16153896http://purl.uniprot.org/core/name"Cancer Cell"xsd:string