| http://purl.uniprot.org/citations/16194878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16194878 | http://www.w3.org/2000/01/rdf-schema#comment | "Bone morphogenetic proteins (BMPs) are important regulators of cellular differentiation and embryonic development. Beta catenin mediated nuclear signaling has been implicated in BMP-2-modulated chondrogenic differentiation in the pluripotential stem cell line C3H10T1/2. However, there is little information on the functional role of beta catenin in BMP-2-modulated differentiation of primary nontransformed mesenchymal cells. Here, we present evidence to show that BMP-2-induced chondrogenic differentiation in high-density primary mesenchymal culture is associated with a significant decrease in membrane-bound beta catenin by 72 hours compared to controls. Nuclear localization of beta catenin is not detectable by immunofluorescence and the TCF-responsive reporter vector TOPFLASH shows only background activity during chondrogenic differentiation. BMP-2-treated cultures show reduced cell-cell adhesion by 72 hours, which correlates with the changes in levels of membrane-bound beta catenin. Up-regulation of membrane-bound beta catenin blocks the effect of BMP-2 on both chondrogenic differentiation and cell-cell adhesiveness. These findings suggest that BMP-2 can modulate the adhesivity of adherens junctions through regulation of membrane bound beta catenin."xsd:string |
| http://purl.uniprot.org/citations/16194878 | http://purl.org/dc/terms/identifier | "doi:10.1080/15419060490951790"xsd:string |
| http://purl.uniprot.org/citations/16194878 | http://purl.uniprot.org/core/author | "Stott N.S."xsd:string |
| http://purl.uniprot.org/citations/16194878 | http://purl.uniprot.org/core/author | "Zhang W.V."xsd:string |
| http://purl.uniprot.org/citations/16194878 | http://purl.uniprot.org/core/date | "2004"xsd:gYear |
| http://purl.uniprot.org/citations/16194878 | http://purl.uniprot.org/core/name | "Cell Commun Adhes"xsd:string |
| http://purl.uniprot.org/citations/16194878 | http://purl.uniprot.org/core/pages | "89-102"xsd:string |
| http://purl.uniprot.org/citations/16194878 | http://purl.uniprot.org/core/title | "BMP-2-modulated chondrogenic differentiation in vitro involves down-regulation of membrane-bound beta-catenin."xsd:string |
| http://purl.uniprot.org/citations/16194878 | http://purl.uniprot.org/core/volume | "11"xsd:string |
| http://purl.uniprot.org/citations/16194878 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16194878 |
| http://purl.uniprot.org/citations/16194878 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16194878 |
| http://purl.uniprot.org/uniprot/P12643#attribution-5736B3D4E455AF3D2CA8729FC3D278C8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16194878 |
| http://purl.uniprot.org/uniprot/P10288#attribution-A36C4531F866A1B83E4D71980EF51173 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16194878 |
| http://purl.uniprot.org/uniprot/P04628#attribution-95A4AC38D35894C8D21A7EB8BD319358 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16194878 |
| http://purl.uniprot.org/uniprot/O42486#attribution-5736B3D4E455AF3D2CA8729FC3D278C8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16194878 |
| http://purl.uniprot.org/uniprot/#_A0A1D5PQN0-mappedCitation-16194878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16194878 |
| http://purl.uniprot.org/uniprot/#_O42486-mappedCitation-16194878 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16194878 |
| http://purl.uniprot.org/uniprot/A0A1D5PQN0 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16194878 |
| http://purl.uniprot.org/uniprot/O42486 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16194878 |