| http://purl.uniprot.org/citations/16216929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16216929 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16216929 | http://www.w3.org/2000/01/rdf-schema#comment | "Immunoglobulin-like Necl-5/Tage4/poliovirus receptor (PVR)/CD155, originally identified as the PVR, has been shown to be up-regulated in cancer cells and to enhance growth factor-induced cell movement and proliferation. In addition, Necl-5 heterophilically trans-interacts with nectin-3, a cell-cell adhesion molecule known to form adherens junctions in cooperation with cadherin. We show here that Necl-5 was down-regulated from cell surface upon cell-cell contacts in NIH3T3 cells. This down-regulation of Necl-5 was initiated by its interaction with nectin-3 and was mainly mediated by clathrin-dependent endocytosis. Then, the down-regulation of Necl-5 induced in this way reduced movement and proliferation of NIH3T3 cells. These results indicate that the down-regulation of Necl-5 induced by its interaction with nectin-3 upon cell-cell contacts may be at least one mechanism underlying contact inhibition of cell movement and proliferation."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200501090"xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.org/dc/terms/identifier | "doi:10.1083/jcb.200501090"xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Minami Y."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Minami Y."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Takai Y."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Takai Y."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Sakamoto Y."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Sakamoto Y."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Kajita M."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Kajita M."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Ikeda W."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Ikeda W."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Monden M."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Monden M."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Kakunaga S."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Kakunaga S."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Fujito T."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/author | "Fujito T."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |
| http://purl.uniprot.org/citations/16216929 | http://purl.uniprot.org/core/name | "J. Cell Biol."xsd:string |