| http://purl.uniprot.org/citations/16220542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16220542 | http://www.w3.org/2000/01/rdf-schema#comment | "The current study explored our hypothesis that IFN-gamma-producing human T cells inhibit human osteoclast formation. Activated T cells derived from human PBMC were divided into IFN-gamma-producing T cells (IFN-gamma(+) T cells) and IFN-gamma-non-producing T cells (IFN-gamma(-) T cells). IFN-gamma(+) T cells were cultured with human monocytes in the presence of macrophage-CSF alone. The concentration of soluble receptor activator of NF-kappaB ligand (RANKL) and IFN-gamma, and the amount of membrane type RANKL expressed on T cells, were measured by ELISA. In the patients with early rheumatoid arthritis (RA) treated with non-steroidal anti-inflammatory drugs alone, CD4+ T cells expressing both IFN-gamma and RANKL were detected by flow cytometry. Surprisingly, IFN-gamma(+) T cells, but not IFN-gamma(-) T cells, induced osteoclastogenesis from monocytes, which was completely inhibited by adding osteoprotegerin and increased by adding anti-IFN-gamma antibodies. The levels of both soluble and membrane type RANKL were elevated in IFN-gamma(+) T cells. The ratio of CD4+ T cells expressing both IFN-gamma and RANKL in total CD4+ T cells from PBMC was elevated in RA patients. Contrary to our hypothesis, IFN-gamma(+) human T cells induced osteoclastogenesis through the expression of RANKL, suggesting that Th1 cells play a direct role in bone resorption in Th1 dominant diseases such as RA."xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.org/dc/terms/identifier | "doi:10.1002/eji.200526141"xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/author | "Furuya T."xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/author | "Kamatani N."xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/author | "Kawamoto M."xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/author | "Togari A."xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/author | "Yago T."xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/author | "Mogi M."xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/author | "Kotake S."xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/author | "Kobashigawa T."xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/author | "Nanke Y."xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/name | "Eur J Immunol"xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/pages | "3353-3363"xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/title | "IFN-gamma-producing human T cells directly induce osteoclastogenesis from human monocytes via the expression of RANKL."xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://purl.uniprot.org/core/volume | "35"xsd:string |
| http://purl.uniprot.org/citations/16220542 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16220542 |
| http://purl.uniprot.org/citations/16220542 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16220542 |
| http://purl.uniprot.org/uniprot/P01579#attribution-AB8F6A1593B98015B7D5C7061BB4A280 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16220542 |
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| http://purl.uniprot.org/uniprot/#_Q54A98-mappedCitation-16220542 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16220542 |
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| http://purl.uniprot.org/uniprot/O14788 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16220542 |
| http://purl.uniprot.org/uniprot/Q5T9Y4 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/16220542 |