| http://purl.uniprot.org/citations/16247484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16247484 | http://www.w3.org/2000/01/rdf-schema#comment | "Mutation or epigenetic silencing of mismatch repair genes, such as MLH1 and MSH2, results in microsatellite instability (MSI) in the genome of a subset of colorectal carcinomas (CRCs). However, little is yet known of genes that directly contribute to tumor formation in such cancers. To characterize MSI-dependent changes in gene expression, we have now compared transcriptomes between fresh CRC specimens positive or negative for MSI (n=10 for each) with the use of high-density oligonucleotide microarrays harboring >44,000 probe sets. Correspondence analysis of the expression patterns of isolated MSI-associated genes revealed that the transcriptome of MSI+ CRCs is clearly distinct from that of MSI-CRCs. Such MSI-associated genes included that for AXIN2, an important component of the WNT signaling pathway. AXIN2 was silenced, apparently as a result of extensive methylation of its promoter region, specifically in MSI+ CRC specimens. Forced expression of AXIN2, either by treatment with 5'-azacytidine or by transfection with AXIN2 cDNA, resulted in rapid cell death in an MSI+ CRC cell line. These data indicate that epigenetic silencing of AXIN2 is specifically associated with carcinogenesis in MSI+ CRCs."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.onc.1209009"xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/author | "Liu W."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/author | "Hatanaka H."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/author | "Wada T."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/author | "Yamashita Y."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/author | "Takada S."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/author | "Nagai H."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/author | "Choi Y.L."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/author | "Kurashina K."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/author | "Mano H."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/author | "Kaneda R."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/author | "Koinuma K."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/author | "Miyakura Y."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/author | "Fujiwara S.I."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/name | "Oncogene"xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/pages | "139-146"xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/title | "Epigenetic silencing of AXIN2 in colorectal carcinoma with microsatellite instability."xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://purl.uniprot.org/core/volume | "25"xsd:string |
| http://purl.uniprot.org/citations/16247484 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16247484 |
| http://purl.uniprot.org/citations/16247484 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16247484 |
| http://purl.uniprot.org/uniprot/#_B7ZKL5-mappedCitation-16247484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16247484 |
| http://purl.uniprot.org/uniprot/#_E7ES00-mappedCitation-16247484 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16247484 |