| http://purl.uniprot.org/citations/16252005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16252005 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16252005 | http://www.w3.org/2000/01/rdf-schema#comment | "Cullin-4 forms a scaffold for multiple ubiquitin ligases. In Schizosaccharomyces pombe, the Cullin-4 homologue (Pcu4) physically associates with Ddb1 and the COP9 signalosome (CSN). One target of this complex is Spd1. Spd1 regulates ribonucleotide reductase (RNR) activity. Spd1 degradation during S phase, or following DNA damage of G2 cells, results in the nuclear export of the small RNR subunit. We demonstrate that Cdt2, an unstable WD40 protein, is a regulatory subunit of Pcu4-Ddb1-CSN ubiquitin ligase. cdt2 deletion stabilises Spd1 and prevents relocalisation of the small RNR subunit from the nucleus to the cytoplasm. cdt2+ is periodically transcribed by the Cdc10/DSC1 transcription factor during S phase and transiently transcribed following DNA damage of G2 cells, corresponding to Spd1 degradation profiles. Cdt2 co-precipitates with Spd1, and Cdt2 overexpression results in constitutive Spd1 degradation. We propose that Cdt2 incorporation into the Pcu4-Ddb1-CSN complex prompts Spd1 targeting and subsequent degradation and that Cdt2 is a WD40 repeat adaptor protein for Cullin-4-based ubiquitin ligase."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600854"xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.org/dc/terms/identifier | "doi:10.1038/sj.emboj.7600854"xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Liu C."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Watson A."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Watson A."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Nielsen O."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Nielsen O."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Shimoda C."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Shimoda C."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Yoshida S.H."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Yoshida S.H."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Carr A.M."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Carr A.M."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Holmberg C."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Holmberg C."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Poitelea M."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/author | "Poitelea M."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |
| http://purl.uniprot.org/citations/16252005 | http://purl.uniprot.org/core/name | "EMBO J."xsd:string |