| http://purl.uniprot.org/citations/16262627 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16262627 | http://www.w3.org/2000/01/rdf-schema#comment | "Tenascin-R (TN-R), a large extracellular glycoprotein, is an important component of the adult brain's extracellular matrix (ECM); tenascin-C (TN-C) is expressed mainly during early development, while human natural killer 1 (HNK-1) is a sulphated carbohydrate epitope that attaches to these molecules, modifying their adhesive properties. To assess their influence on extracellular space (ECS) volume and geometry, we used the real-time iontophoretic method to measure ECS volume fraction alpha and tortuosity lambda, and diffusion-weighted magnetic resonance imaging (MRI) to measure the apparent diffusion coefficient of water (ADC(W)). Measurements were performed in vivo in the cortex and CA1 hippocampal region of TN-R-, TN-C- and HNK-1 sulphotransferase (ST)-deficient adult mice and their wild-type littermate controls. In both cortex and hippocampus, the lack of TN-R or HNK-1 sulphotransferase resulted in a significant decrease in alpha and lambda. Compared with controls, alpha in TN-R-/- and ST-/-mice decreased by 22-26% and 9-15%, respectively. MRI measurements revealed a decreased ADC(W) in the cortex, hippocampus and thalamus. ADC(W) reflected the changes in alpha; the decrease in lambda indicated fewer diffusion obstacles in the ECS, presumably due to a decreased macromolecular content. No significant changes were found in TN-C-/- animals. We conclude that in TN-R-/- and ST-/-mice, which show morphological, electrophysiological and behavioural abnormalities, the ECS is reduced and its geometry altered. TN-R, as an important component of the ECM, appears to maintain an optimal distance between cells. The altered diffusion of neuroactive substances in the brain will inevitably affect extrasynaptic transmission, neuron-glia interactions and synaptic efficacy."xsd:string |
| http://purl.uniprot.org/citations/16262627 | http://purl.org/dc/terms/identifier | "doi:10.1111/j.1460-9568.2005.04375.x"xsd:string |
| http://purl.uniprot.org/citations/16262627 | http://purl.uniprot.org/core/author | "Schachner M."xsd:string |
| http://purl.uniprot.org/citations/16262627 | http://purl.uniprot.org/core/author | "Mazel T."xsd:string |
| http://purl.uniprot.org/citations/16262627 | http://purl.uniprot.org/core/author | "Antonova T."xsd:string |
| http://purl.uniprot.org/citations/16262627 | http://purl.uniprot.org/core/author | "Sykova E."xsd:string |
| http://purl.uniprot.org/citations/16262627 | http://purl.uniprot.org/core/author | "Vorisek I."xsd:string |
| http://purl.uniprot.org/citations/16262627 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16262627 | http://purl.uniprot.org/core/name | "Eur J Neurosci"xsd:string |
| http://purl.uniprot.org/citations/16262627 | http://purl.uniprot.org/core/pages | "1873-1880"xsd:string |
| http://purl.uniprot.org/citations/16262627 | http://purl.uniprot.org/core/title | "Reduced extracellular space in the brain of tenascin-R- and HNK-1-sulphotransferase deficient mice."xsd:string |
| http://purl.uniprot.org/citations/16262627 | http://purl.uniprot.org/core/volume | "22"xsd:string |
| http://purl.uniprot.org/citations/16262627 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16262627 |
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