| http://purl.uniprot.org/citations/16301533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16301533 | http://www.w3.org/2000/01/rdf-schema#comment | "Vacuole biogenesis depends on specific targeting and retention of peripheral membrane proteins. At least three palmitoylated proteins are found exclusively on yeast vacuoles: the fusion factor Vac8, the kinase Yck3, and a novel adaptor protein implicated in microautophagy, Meh1. Here, we analyze the role that putative acyltransferases of the DHHC family play in their localization and function. We find that Pfa3/Ynl326c is required for efficient localization of Vac8 to vacuoles in vivo, while Yck3 or Meh1 localization is not impaired in any of the seven DHHC deletions. Vacuole-associated Vac8 appears to be palmitoylated in a pfa3 mutant, but this population is refractive to further palmitoylation on isolated vacuoles. Vacuole morphology and inheritance, which both depend on Vac8 palmitoylation, appear normal, although there is a reduction in vacuole fusion. Interestingly, Pfa3 is required for the vacuolar localization of not only an SH4 domain that is targeted by myristate/palmitate (as in Vac8) but also one that is targeted by a myristate/basic stretch (as in Src). Our data indicate that Pfa3 has an important but not exclusive function for Vac8 localization to the vacuole."xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0508885102"xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://purl.uniprot.org/core/author | "LaGrassa T.J."xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://purl.uniprot.org/core/author | "Hou H."xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://purl.uniprot.org/core/author | "Ungermann C."xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://purl.uniprot.org/core/author | "Urban J."xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://purl.uniprot.org/core/author | "Dietrich L.E."xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://purl.uniprot.org/core/author | "Subramanian K."xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://purl.uniprot.org/core/author | "Decker N."xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://purl.uniprot.org/core/author | "Markgraf D."xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16301533 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://purl.uniprot.org/core/pages | "17366-17371"xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://purl.uniprot.org/core/title | "The DHHC protein Pfa3 affects vacuole-associated palmitoylation of the fusion factor Vac8."xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/16301533 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16301533 |
| http://purl.uniprot.org/citations/16301533 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16301533 |
| http://purl.uniprot.org/uniprot/P39962#attribution-FEE07A65E16B115CFED9970FFFB79CC8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16301533 |
| http://purl.uniprot.org/uniprot/Q02205#attribution-FEE07A65E16B115CFED9970FFFB79CC8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16301533 |
| http://purl.uniprot.org/uniprot/P42836#attribution-32FE8D014C48D3EF85B3F39B615C9FF7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16301533 |
| http://purl.uniprot.org/uniprot/P42836#attribution-FEE07A65E16B115CFED9970FFFB79CC8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16301533 |
| http://purl.uniprot.org/uniprot/P39968#attribution-32FE8D014C48D3EF85B3F39B615C9FF7 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16301533 |
| http://purl.uniprot.org/uniprot/P39968#attribution-FEE07A65E16B115CFED9970FFFB79CC8 | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16301533 |
| http://purl.uniprot.org/uniprot/#_A0A8H4BVD6-mappedCitation-16301533 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16301533 |