| http://purl.uniprot.org/citations/1630491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/1630491 | http://www.w3.org/2000/01/rdf-schema#comment | "A role in folding of newly translated proteins in the cytosol of eukaryotes has been proposed for t-complex polypeptide-1 (TCP1), although its molecular targets have not yet been identified. Tubulin is a major cytosolic protein whose assembly into microtubules is critical to many cellular processes. Although numerous studies have focused on the expression of tubulin, little is known about the processes whereby newly translated tubulin subunits acquire conformations that enable them to form alpha-beta-heterodimers. We examined the biogenesis of alpha- and beta-tubulin in rabbit reticulocyte lysate, and report here that newly translated tubulin subunits entered a 900K complex in a protease-sensitive conformation. Addition of Mg-ATP, but not nonhydrolysable analogues, released the tubulin subunits as assembly-competent protein with a conformation that was relatively protease-resistant. The 900K complex purified from reticulocyte lysate contained as its major constituent a 58K protein that cross-reacted with a monoclonal antiserum against mouse TCP1. We conclude that TCP1 functions as a cytosolic chaperone in the biogenesis of tubulin."xsd:string |
| http://purl.uniprot.org/citations/1630491 | http://purl.org/dc/terms/identifier | "doi:10.1038/358245a0"xsd:string |
| http://purl.uniprot.org/citations/1630491 | http://purl.uniprot.org/core/author | "Yaffe M.B."xsd:string |
| http://purl.uniprot.org/citations/1630491 | http://purl.uniprot.org/core/author | "Horwich A.L."xsd:string |
| http://purl.uniprot.org/citations/1630491 | http://purl.uniprot.org/core/author | "Farr G.W."xsd:string |
| http://purl.uniprot.org/citations/1630491 | http://purl.uniprot.org/core/author | "Miklos D."xsd:string |
| http://purl.uniprot.org/citations/1630491 | http://purl.uniprot.org/core/author | "Sternlicht H."xsd:string |
| http://purl.uniprot.org/citations/1630491 | http://purl.uniprot.org/core/author | "Sternlicht M.L."xsd:string |
| http://purl.uniprot.org/citations/1630491 | http://purl.uniprot.org/core/date | "1992"xsd:gYear |
| http://purl.uniprot.org/citations/1630491 | http://purl.uniprot.org/core/name | "Nature"xsd:string |
| http://purl.uniprot.org/citations/1630491 | http://purl.uniprot.org/core/pages | "245-248"xsd:string |
| http://purl.uniprot.org/citations/1630491 | http://purl.uniprot.org/core/title | "TCP1 complex is a molecular chaperone in tubulin biogenesis."xsd:string |
| http://purl.uniprot.org/citations/1630491 | http://purl.uniprot.org/core/volume | "358"xsd:string |
| http://purl.uniprot.org/citations/1630491 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/1630491 |
| http://purl.uniprot.org/citations/1630491 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/1630491 |
| http://purl.uniprot.org/uniprot/#_E7EQR6-mappedCitation-1630491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1630491 |
| http://purl.uniprot.org/uniprot/#_P17987-mappedCitation-1630491 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/1630491 |
| http://purl.uniprot.org/uniprot/E7EQR6 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1630491 |
| http://purl.uniprot.org/uniprot/P17987 | http://purl.uniprot.org/core/mappedCitation | http://purl.uniprot.org/citations/1630491 |