| http://purl.uniprot.org/citations/16306267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16306267 | http://www.w3.org/2000/01/rdf-schema#comment | "Cellular responses to hypoxia are tissue-specific and dynamic. However, the mechanisms that underlie this differential sensitivity to hypoxia are unknown. Large conductance voltage- and Ca-activated K (BK) channels are important mediators of hypoxia responses in many systems. Although BK channels are ubiquitously expressed, alternative pre-mRNA splicing of the single gene encoding their pore-forming alpha-subunits provides a powerful mechanism for generating functional diversity. Here, we demonstrate that the hypoxia sensitivity of BK channel alpha-subunits is splice-variant-specific. Sensitivity to hypoxia is conferred by a highly conserved motif within an alternatively spliced cysteine-rich insert, the stress-regulated exon (STREX), within the intracellular C terminus of the channel. Hypoxic inhibition of the STREX variant is Ca-sensitive and reversible, and it rapidly follows the change in oxygen tension by means of a mechanism that is independent of redox or CO regulation. Hypoxia sensitivity was abolished by mutation of the serine (S24) residue within the STREX insert. Because STREX splice-variant expression is tissue-specific and dynamically controlled, alternative splicing of BK channels provides a mechanism to control the plasticity of cellular responses to hypoxia."xsd:string |
| http://purl.uniprot.org/citations/16306267 | http://purl.org/dc/terms/identifier | "doi:10.1073/pnas.0505270102"xsd:string |
| http://purl.uniprot.org/citations/16306267 | http://purl.uniprot.org/core/author | "Rowan E.G."xsd:string |
| http://purl.uniprot.org/citations/16306267 | http://purl.uniprot.org/core/author | "McClafferty H."xsd:string |
| http://purl.uniprot.org/citations/16306267 | http://purl.uniprot.org/core/author | "Rowe I.C."xsd:string |
| http://purl.uniprot.org/citations/16306267 | http://purl.uniprot.org/core/author | "Shipston M.J."xsd:string |
| http://purl.uniprot.org/citations/16306267 | http://purl.uniprot.org/core/author | "Huibant J.M."xsd:string |
| http://purl.uniprot.org/citations/16306267 | http://purl.uniprot.org/core/author | "McCartney C.E."xsd:string |
| http://purl.uniprot.org/citations/16306267 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16306267 | http://purl.uniprot.org/core/name | "Proc Natl Acad Sci U S A"xsd:string |
| http://purl.uniprot.org/citations/16306267 | http://purl.uniprot.org/core/pages | "17870-17876"xsd:string |
| http://purl.uniprot.org/citations/16306267 | http://purl.uniprot.org/core/title | "A cysteine-rich motif confers hypoxia sensitivity to mammalian large conductance voltage- and Ca-activated K (BK) channel alpha-subunits."xsd:string |
| http://purl.uniprot.org/citations/16306267 | http://purl.uniprot.org/core/volume | "102"xsd:string |
| http://purl.uniprot.org/citations/16306267 | http://www.w3.org/2004/02/skos/core#exactMatch | http://purl.uniprot.org/pubmed/16306267 |
| http://purl.uniprot.org/citations/16306267 | http://xmlns.com/foaf/0.1/primaryTopicOf | https://pubmed.ncbi.nlm.nih.gov/16306267 |
| http://purl.uniprot.org/uniprot/Q08460#attribution-D01D3AD17A3126BCD911A98426F474BE | http://purl.uniprot.org/core/source | http://purl.uniprot.org/citations/16306267 |
| http://purl.uniprot.org/uniprot/#_A0A087WQ41-mappedCitation-16306267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16306267 |
| http://purl.uniprot.org/uniprot/#_A0A087WQE1-mappedCitation-16306267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16306267 |
| http://purl.uniprot.org/uniprot/#_A0A087WQN5-mappedCitation-16306267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16306267 |
| http://purl.uniprot.org/uniprot/#_A0A087WRS4-mappedCitation-16306267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16306267 |
| http://purl.uniprot.org/uniprot/#_A0A087WSQ4-mappedCitation-16306267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16306267 |
| http://purl.uniprot.org/uniprot/#_E9Q9P4-mappedCitation-16306267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16306267 |
| http://purl.uniprot.org/uniprot/#_A0A286YCW3-mappedCitation-16306267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16306267 |
| http://purl.uniprot.org/uniprot/#_A0A286YCZ9-mappedCitation-16306267 | http://www.w3.org/1999/02/22-rdf-syntax-ns#object | http://purl.uniprot.org/citations/16306267 |