| http://purl.uniprot.org/citations/16317009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16317009 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16317009 | http://www.w3.org/2000/01/rdf-schema#comment | "Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3'-exoribonuclease. Here we have investigated how the cap binding complex (CBC) affects human PARN activity. We showed that CBC, via its 80-kDa subunit (CBP80), inhibited PARN, suggesting that CBC can regulate mRNA deadenylation. The CBC-mediated inhibition of PARN was cap-independent, and in keeping with this, the CBP80 subunit alone inhibited PARN. Our data suggested a new function for CBC, identified CBC as a potential regulator of PARN, and emphasized the importance of communication between the two extreme ends of the mRNA as a key strategy to regulate mRNA degradation. Based on our data, we have proposed a model for CBC-mediated regulation of PARN, which relies on an interaction between CBP80 and PARN. Association of CBC with PARN might have importance in the regulated recruitment of PARN to the nonsense-mediated decay pathway during the pioneer round of translation."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m508590200"xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.org/dc/terms/identifier | "doi:10.1074/jbc.m508590200"xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/author | "Nilsson P."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/author | "Nilsson P."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/author | "Cusack S."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/author | "Cusack S."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/author | "Virtanen A."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/author | "Virtanen A."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/author | "Mazza C."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/author | "Mazza C."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/author | "Balatsos N.A.A."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/author | "Balatsos N.A.A."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/date | "2006"xsd:gYear |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/name | "J. Biol. Chem."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/pages | "4517-4522"xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/pages | "4517-4522"xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/title | "Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC)."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/title | "Inhibition of mRNA deadenylation by the nuclear cap binding complex (CBC)."xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/volume | "281"xsd:string |
| http://purl.uniprot.org/citations/16317009 | http://purl.uniprot.org/core/volume | "281"xsd:string |