| http://purl.uniprot.org/citations/16337594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16337594 | http://www.w3.org/1999/02/22-rdf-syntax-ns#type | http://purl.uniprot.org/core/Journal_Citation |
| http://purl.uniprot.org/citations/16337594 | http://www.w3.org/2000/01/rdf-schema#comment | "Inactivation of retinoblastoma protein (Rb) plays a critical role in the development of human malignancies. It has been shown that Rb is degraded through a proteasome-dependent pathway, yet the mechanism is largely unclear. MDM2 is frequently found amplified and overexpressed in a variety of human tumors. In this study, we find that MDM2 promotes Rb degradation in a proteasome-dependent and ubiquitin-independent manner. We show that Rb, MDM2, and the C8 subunit of the 20S proteasome interact in vitro and in vivo and that MDM2 promotes Rb-C8 interaction. Expression of wild-type MDM2, but not the mutant MDM2 defective either in Rb interaction or in RING finger domain, promotes cell cycle S phase entry independent of p53. Furthermore, MDM2 ablation results in Rb accumulation and inhibition of DNA synthesis. Taken together, these findings demonstrate that MDM2 is a critical negative regulator for Rb and suggest that MDM2 overexpression contributes to cancer development by destabilizing Rb."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.10.017"xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.org/dc/terms/identifier | "doi:10.1016/j.molcel.2005.10.017"xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Zheng H."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Zheng H."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Qiu W."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Qiu W."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Allday M.J."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Allday M.J."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Touitou R."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Touitou R."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Ying H."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Ying H."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Xiao Z.X."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Xiao Z.X."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Chang D.L."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Chang D.L."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Sdek P."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/author | "Sdek P."xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/date | "2005"xsd:gYear |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |
| http://purl.uniprot.org/citations/16337594 | http://purl.uniprot.org/core/name | "Mol. Cell"xsd:string |